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    Mtmr3 myotubularin related protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 74302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtmr3provided by MGI
    Official Full Name
    myotubularin related protein 3provided by MGI
    Primary source
    MGI:MGI:1921552
    See related
    Ensembl:ENSMUSG00000034354 AllianceGenome:MGI:1921552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZFYVE10; FYVE-DSP1; mKIAA0371; 1700092A20Rik
    Summary
    Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.9), thymus adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtmr3 in Genome Data Viewer
    Location:
    11 A1; 11 2.94 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4430867..4544863, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4480867..4594863, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24803 Neighboring gene HORMA domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_28383 Neighboring gene STARR-seq mESC enhancer starr_28385 Neighboring gene STARR-positive B cell enhancer ABC_E5204 Neighboring gene STARR-seq mESC enhancer starr_28386 Neighboring gene STARR-seq mESC enhancer starr_28391 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E728 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene predicted gene 11961 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_28397

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking. Dewi Pamungkas Putri D, et al. J Biol Chem, 2019 May 24. PMID 30944173, Free PMC Article
    2. MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy. Wang YN, et al. Kidney Int, 2023 Sep. PMID 37414396
    3. SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Wei N, et al. Cell Rep, 2015 Nov 24. PMID 26586428
    4. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
      Title: MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
    2. these results suggest that MTMR3 and MTMR4 regulate the production of PtdIns3P, which plays a critical role in suppressing DNA-mediated innate immune responses via modulating STING trafficking.
      Title: PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC78036

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 5-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; myotubularin-related protein 3
    Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase
    phosphatidylinositol-3-phosphate phosphatase
    NP_001360826.1
    NP_083136.2
    XP_006514908.1
    XP_006514909.1
    XP_006514911.1
    XP_036012929.1
    XP_036012930.1
    XP_036012931.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373897.1 → NP_001360826.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606521, AL645910
      UniProtKB/Swiss-Prot
      Q5NCA4, Q8K296
      UniProtKB/TrEMBL
      R4GML8
      Related
      ENSMUSP00000122422.3, ENSMUST00000123506.9
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1113 → 1173
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    2. NM_028860.2 → NP_083136.2  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform 2

      See identical proteins and their annotated locations for NP_083136.2

      Status: VALIDATED

      Source sequence(s)
      AK122261, AK141138, AW046647, CB249296, CB527330, CF532066, CJ048010, CV557784, CX566279
      Consensus CDS
      CCDS48744.1
      UniProtKB/TrEMBL
      B1ATD5, Q66I45
      Related
      ENSMUSP00000105569.4, ENSMUST00000109943.10
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1076 → 1136
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4430867..4544863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157038.1 → XP_036012931.1  myotubularin-related protein 3 isoform X4

      UniProtKB/TrEMBL
      M0QW74
      Related
      ENSMUSP00000137687.2, ENSMUST00000130716.8
      Conserved Domains (2) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    2. XM_006514848.4 → XP_006514911.1  myotubularin-related protein 3 isoform X2

      UniProtKB/TrEMBL
      B1ATD4, Q66I45
      Related
      ENSMUSP00000116315.3, ENSMUST00000128256.3
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1076 → 1145
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    3. XM_006514845.4 → XP_006514908.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006514908.1

      UniProtKB/TrEMBL
      A0AAQ4VMT1, R4GML8
      Related
      ENSMUSP00000159982.1, ENSMUST00000249885.1
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1113 → 1182
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    4. XM_006514846.4 → XP_006514909.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006514909.1

      UniProtKB/TrEMBL
      A0AAQ4VMT1, R4GML8
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1113 → 1182
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    5. XM_036157036.1 → XP_036012929.1  myotubularin-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0AAQ4VMT1, R4GML8
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1113 → 1182
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    6. XM_036157037.1 → XP_036012930.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      B1ATD5, Q66I45
      Conserved Domains (3) summary
      cd13341
      Location:23 → 116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:1076 → 1136
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169 → 485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

    RNA

    1. XR_003949519.1 RNA Sequence

      Related
      ENSMUST00000249884.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K296.2 GenPept UniProtKB/Swiss-Prot:Q8K296

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