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    insb insensible [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    insbprovided by FlyBase
    Official Full Name
    insensibleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034224
    Locus tag
    Dmel_CG6520
    See related
    AllianceGenome:FB:FBgn0034224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6520; Dmel\CG6520
    Summary
    Involved in negative regulation of Notch signaling pathway. Located in nucleus. Is expressed in mesonotum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See insb in Genome Data Viewer
    Location:
    54B16-54B16; 2-82 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17475214..17476272, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13362719..13363777, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Testin Neighboring gene quaking related 54B Neighboring gene uncharacterized protein Neighboring gene veil Neighboring gene Ecto-5'-nucleotidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nonneural miRNA cluster mediates hearing via repression of two neural targets. Zhang B, et al. Genes Dev, 2023 Dec 26. PMID 38110249, Free PMC Article
    2. Insensible is a novel nuclear inhibitor of Notch activity in Drosophila. Coumailleau F, et al. PLoS One, 2014. PMID 24902027, Free PMC Article
    3. Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division. Komori H, et al. Genes Dev, 2018 Dec 1. PMID 30463902, Free PMC Article
    4. miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. Kavaler J, et al. J Cell Biol, 2018 Feb 5. PMID 29196461, Free PMC Article
    5. Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes. Rives-Quinto N, et al. Elife, 2020 Nov 26. PMID 33241994, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insensible
    Names
    CG6520-PA
    CG6520-PB
    insb-PA
    insb-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17475214..17476272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299602.1 → NP_001286531.1  insensible, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZ51

    2. NM_137372.4 → NP_611216.1  insensible, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZ51
      Related
      FBpp0086109
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZ51 Q7JZ51

    Gene LinkOut

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