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    Rrp42 Rrp42 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36766, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rrp42provided by FlyBase
    Official Full Name
    Rrp42provided by FlyBase
    Primary source
    FLYBASE:FBgn0034065
    Locus tag
    Dmel_CG8395
    See related
    AllianceGenome:FB:FBgn0034065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey140; anon-EST:Posey187; CG8395; Dmel\CG8395; dRrp42
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Located in cytoplasm and nuclear lamina. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC7 (exosome component 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rrp42 in Genome Data Viewer
    Location:
    52D14-52D14; 2-76 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16014908..16016050)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11902413..11903555)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta1 subunit Neighboring gene ER membrane protein complex subunit 7 Neighboring gene uncharacterized protein Neighboring gene caspar

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Graham AC, et al. Mol Biol Cell, 2006 Mar. PMID 16407406, Free PMC Article
    2. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
    3. Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Mamolen M, et al. Nucleic Acids Res, 2010 Sep. PMID 20421210, Free PMC Article
    4. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225
    5. Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Graham AC, et al. Traffic, 2009 May. PMID 19220816, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rrp42
    Names
    CG8395-PA
    Rrp42-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16014908..16016050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166134.3 → NP_725517.2  Rrp42 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725517.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QQ9
      Related
      FBpp0086348
      Conserved Domains (2) summary
      cd11367
      Location:5 → 278
      RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome
      COG2123
      Location:6 → 277
      Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29QQ9 Q29QQ9

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