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    CG8320 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8320provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034059
    Locus tag
    Dmel_CG8320
    See related
    AllianceGenome:FB:FBgn0034059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8320
    Summary
    Enables signaling receptor binding activity. Acts upstream of with a positive effect on protein localization involved in establishment of planar polarity. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; gut section; and salivary gland body primordium. Used to study syndromic intellectual disability. Orthologous to human TMEM208 (transmembrane protein 208). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8320 in Genome Data Viewer
    Location:
    52D9-52D10; 2-76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15992408..15993707)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11879913..11881212)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxin 11a/b Neighboring gene ATP citrate lyase Neighboring gene Transmembrane protein 131 Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    2. Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster. Kumar S, et al. J Biol Rhythms, 2021 Jun. PMID 33274675, Free PMC Article
    3. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
    4. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article
    5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect protein localization involved in establishment of planar polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuolar protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8320-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15992408..15993707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137228.4 → NP_611072.2  uncharacterized protein Dmel_CG8320 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611072.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZA77, Q8SZE6
      Related
      FBpp0086344
      Conserved Domains (1) summary
      pfam05620
      Location:11 → 167
      DUF788; Protein of unknown function (DUF788)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA77 A1ZA77
    Q8SZE6 Q8SZE6

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