Apc2 APC regulator of WNT signaling pathway 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apc2provided by RGD
Official Full Name: APC regulator of WNT signaling pathway 2provided by RGD
Primary source: RGD:1308256
See related: EnsemblRapid:ENSRNOG00000033791 AllianceGenome:RGD:1308256
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Is active in postsynapse. Human ortholog(s) of this gene implicated in Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; complex cortical dysplasia with other brain malformations; and nicotine dependence. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 103.5), Heart (RPKM 20.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10043010..10065037, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9392336..9414364, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12258468..12280459, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains.
Title: APC2 controls dendrite development by promoting microtubule dynamics.
Hypomethylation of PTGS2, and hypermethylation of APC2 may be causally linked to the etiology of oral cancer in a rat model.
Title: Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide.

Submit: New GeneRIF Correction

General gene information

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Markers

AW527321 (e-PCR)
- UniSTS:246024

BE096640 (e-PCR)
- UniSTS:260644

RH132628 (e-PCR)
- UniSTS:215911

D1S3693 (e-PCR)
- UniSTS:474271

RH139351 (e-PCR)
- UniSTS:221437

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenomatous polyposis coli protein 2

Names: APC2, WNT signaling pathway regulator; adenomatosis polyposis coli 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106769.2 → NP_001100239.2 adenomatous polyposis coli protein 2

See identical proteins and their annotated locations for NP_001100239.2

Status: INFERRED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2JZW4, A6K8M9

Related

ENSRNOP00000045757.5, ENSRNOT00000049146.6

Conserved Domains (9) summary

cd00020
Location:574 → 692

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1377 → 1401

APC_crr; APC cysteine-rich region

pfam05924
Location:1602 → 1620

SAMP; SAMP Motif

pfam05937
Location:2208 → 2256

EB1_binding; EB-1 Binding Domain

pfam05956
Location:1764 → 2089

APC_basic; APC basic domain

pfam11414
Location:124 → 205

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:695 → 941

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:525 → 558

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10043010..10065037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078649.1 → XP_038934577.1 adenomatous polyposis coli protein 2 isoform X6

UniProtKB/TrEMBL

A6K8M9, D4A205

Conserved Domains (11) summary

PHA03247
Location:1527 → 1952

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:548 → 581

ARM; armadillo repeat [structural motif]

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:636 → 675

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1400 → 1422

APC_r; APC repeat

pfam05924
Location:1621 → 1642

SAMP; SAMP Motif

pfam05937
Location:2231 → 2279

EB1_binding; EB-1 Binding Domain

pfam05956
Location:1787 → 2119

APC_basic; APC basic domain

pfam11414
Location:148 → 228

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:718 → 964

Arm_APC_u3; Armadillo-associated region on APC

pfam18797
Location:379 → 452

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_006240878.4 → XP_006240940.1 adenomatous polyposis coli protein 2 isoform X5

UniProtKB/TrEMBL

A6K8M9

Related

ENSRNOP00000106347.1, ENSRNOT00000130794.1

Conserved Domains (9) summary

cd00020
Location:598 → 716

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1401 → 1425

APC_crr; APC cysteine-rich region

pfam05924
Location:1626 → 1644

SAMP; SAMP Motif

pfam05937
Location:2232 → 2280

EB1_binding; EB-1 Binding Domain

pfam05956
Location:1788 → 2113

APC_basic; APC basic domain

pfam11414
Location:148 → 229

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:719 → 965

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:549 → 582

ARM; armadillo repeat [structural motif]
XM_039078648.1 → XP_038934576.1 adenomatous polyposis coli protein 2 isoform X2

UniProtKB/TrEMBL

A6K8M9

Conserved Domains (11) summary

PHA03247
Location:1534 → 1959

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:555 → 588

ARM; armadillo repeat [structural motif]

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:643 → 682

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1407 → 1429

APC_r; APC repeat

pfam05924
Location:1628 → 1649

SAMP; SAMP Motif

pfam05937
Location:2238 → 2286

EB1_binding; EB-1 Binding Domain

pfam05956
Location:1794 → 2126

APC_basic; APC basic domain

pfam11414
Location:148 → 235

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:725 → 971

Arm_APC_u3; Armadillo-associated region on APC

pfam18797
Location:386 → 459

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_063263171.1 → XP_063119241.1 adenomatous polyposis coli protein 2 isoform X8

UniProtKB/TrEMBL

A0A0G2JZW4, A6K8M9

Related

ENSRNOP00000071210.2, ENSRNOT00000086061.3
XM_039078650.2 → XP_038934578.1 adenomatous polyposis coli protein 2 isoform X7

UniProtKB/TrEMBL

A6K8M9

Conserved Domains (10) summary

PHA03247
Location:1510 → 1935

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:531 → 564

ARM; armadillo repeat [structural motif]

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:619 → 658

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1383 → 1405

APC_r; APC repeat

pfam05924
Location:1604 → 1625

SAMP; SAMP Motif

pfam05956
Location:1770 → 2102

APC_basic; APC basic domain

pfam11414
Location:124 → 211

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:701 → 947

Arm_APC_u3; Armadillo-associated region on APC

pfam18797
Location:362 → 435

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_063263172.1 → XP_063119242.1 adenomatous polyposis coli protein 2 isoform X9

UniProtKB/TrEMBL

A6K8M9
XM_039078651.2 → XP_038934579.1 adenomatous polyposis coli protein 2 isoform X7

UniProtKB/TrEMBL

A6K8M9

Conserved Domains (10) summary

PHA03247
Location:1510 → 1935

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:531 → 564

ARM; armadillo repeat [structural motif]

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:619 → 658

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1383 → 1405

APC_r; APC repeat

pfam05924
Location:1604 → 1625

SAMP; SAMP Motif

pfam05956
Location:1770 → 2102

APC_basic; APC basic domain

pfam11414
Location:124 → 211

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:701 → 947

Arm_APC_u3; Armadillo-associated region on APC

pfam18797
Location:362 → 435

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_039078652.2 → XP_038934580.1 adenomatous polyposis coli protein 2 isoform X7

UniProtKB/TrEMBL

A6K8M9

Conserved Domains (10) summary

PHA03247
Location:1510 → 1935

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:531 → 564

ARM; armadillo repeat [structural motif]

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:619 → 658

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1383 → 1405

APC_r; APC repeat

pfam05924
Location:1604 → 1625

SAMP; SAMP Motif

pfam05956
Location:1770 → 2102

APC_basic; APC basic domain

pfam11414
Location:124 → 211

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:701 → 947

Arm_APC_u3; Armadillo-associated region on APC

pfam18797
Location:362 → 435

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_039078647.2 → XP_038934575.1 adenomatous polyposis coli protein 2 isoform X1

UniProtKB/TrEMBL

A6K8M9

Conserved Domains (11) summary

PHA03247
Location:1538 → 1963

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:559 → 592

ARM; armadillo repeat [structural motif]

pfam16689
Location:34 → 85

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:647 → 686

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1411 → 1433

APC_r; APC repeat

pfam05924
Location:1632 → 1653

SAMP; SAMP Motif

pfam05937
Location:2242 → 2290

EB1_binding; EB-1 Binding Domain

pfam05956
Location:1798 → 2130

APC_basic; APC basic domain

pfam11414
Location:152 → 239

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:729 → 975

Arm_APC_u3; Armadillo-associated region on APC

pfam18797
Location:390 → 463

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_017594717.3 → XP_017450206.1 adenomatous polyposis coli protein 2 isoform X4

UniProtKB/TrEMBL

A6K8M9

Related

ENSRNOP00000102706.1, ENSRNOT00000172189.1
XM_017594716.3 → XP_017450205.1 adenomatous polyposis coli protein 2 isoform X3

UniProtKB/TrEMBL

A6K8M9