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    Vps16A Vacuolar protein sorting 16A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41107, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps16Aprovided by FlyBase
    Official Full Name
    Vacuolar protein sorting 16Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285911
    Locus tag
    Dmel_CG8454
    See related
    AllianceGenome:FB:FBgn0285911
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8454; Dmel\CG8454; DmVps16; dVps16A; ma; V16; Vps16; vps16a; vps16A; Vps16a
    Summary
    Contributes to syntaxin binding activity. Involved in several processes, including autophagosome maturation; crinophagy; and vesicle organization. Located in cytosol; endosome; and vacuole. Part of CORVET complex and HOPS complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in dystonia 30. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps16A in Genome Data Viewer
    Location:
    85D7-85D7; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9267019..9270224)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5092741..5095946)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene salivary gland-expressed bHLH Neighboring gene Tryptophanyl-tRNA synthetase Neighboring gene long non-coding RNA:CR46350 Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1e

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maroon: A Recurrent Mutation in Drosophila. Bridges CB. Proc Natl Acad Sci U S A, 1918 Oct. PMID 16576317, Free PMC Article
    2. An Eye on Trafficking Genes: Identification of Four Eye Color Mutations in Drosophila. Grant P, et al. G3 (Bethesda), 2016 Oct 13. PMID 27558665, Free PMC Article
    3. Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity. Takáts S, et al. Autophagy, 2015. PMID 26061715, Free PMC Article
    4. Rab2 promotes autophagic and endocytic lysosomal degradation. Lőrincz P, et al. J Cell Biol, 2017 Jul 3. PMID 28483915, Free PMC Article
    5. Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. Chi C, et al. J Biol Chem, 2010 Jul 9. PMID 20418542, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vps16A reduces autophagosome numbers both by indirectly restricting their formation rate and by directly promoting their clearance
      Title: Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity.
    2. Results describe the novel Ema gene family, identify a new component of the endosomal pathway and provide insights into class C Vps16A-HOPS complex function.
      Title: The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation.
    3. Here we demonstrate that dVps16A (CG8454) encodes another subunit of the Vps-C protein complex required for endosomal trafficking and pigment-granule biogenesis. Drosophila Vps16A is essential for lysosomal trafficking
      Title: Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in crinophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in endosomal vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye pigment granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of SNARE complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuole organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CORVET complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HOPS complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of HOPS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of HOPS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 16A
    Names
    CG8454-PA
    Vps16
    Vps16A-PA
    maroon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9267019..9270224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141620.3 → NP_649877.1  vacuolar protein sorting 16A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHG1
      UniProtKB/TrEMBL
      A0A2Z1YTP5
      Related
      FBpp0081459
      Conserved Domains (2) summary
      pfam04841
      Location:6 → 421
      Vps16_N; Vps16, N-terminal region
      pfam04840
      Location:515 → 829
      Vps16_C; Vps16, C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHG1 Q9VHG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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