Tap42 Two A-associated protein of 42kDa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tap42provided by FlyBase
Official Full Name: Two A-associated protein of 42kDaprovided by FlyBase
Primary source: FLYBASE:FBgn0051852
Locus tag: Dmel_CG31852
See related: AllianceGenome:FB:FBgn0051852
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31852; CG6537; Dmel\CG31852; dTap42; Tap-42/CG31852
Summary: Enables protein phosphatase inhibitor activity. Involved in mitotic spindle organization and wing disc morphogenesis. Part of protein phosphatase type 2A complex. Is expressed in antennal disc; haltere disc; mesothoracic leg disc; metathoracic leg disc; and wing disc. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to human IGBP1C (IGBP1 family member C) and IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13367617..13369021)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13367617..13369021)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Tap42*phosphatase complexes play crucial roles in governing imaginal disc and fly development.
Title: Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster.
tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila
Title: The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain