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    Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313510, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Atpaf1provided by RGD
    Official Full Name
    ATP synthase mitochondrial F1 complex assembly factor 1provided by RGD
    Primary source
    RGD:1305417
    See related
    EnsemblRapid:ENSRNOG00000010169 AllianceGenome:RGD:1305417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-containing complex stabilizing activity. Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human ATPAF1 (ATP synthase mitochondrial F1 complex assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 90.0), Kidney (RPKM 86.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atpaf1 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134503164..134530323)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129265789..129292463)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134641618..134667079)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 14 Neighboring gene testis expressed 38 Neighboring gene MOB kinase activator 3C Neighboring gene MAPK interacting serine/threonine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex stabilizing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP synthase mitochondrial F1 complex assembly factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107959.2 → NP_001101429.1  ATP synthase mitochondrial F1 complex assembly factor 1

      See identical proteins and their annotated locations for NP_001101429.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JZ48, D3ZY50
      Related
      ENSRNOP00000013533.5, ENSRNOT00000013533.7
      Conserved Domains (1) summary
      pfam06644
      Location:99 → 327
      ATP11; ATP11 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134503164..134530323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109988.2 → XP_038965916.1  ATP synthase mitochondrial F1 complex assembly factor 1 isoform X1

      Conserved Domains (1) summary
      pfam06644
      Location:99 → 246
      ATP11; ATP11 protein

    2. XM_017593384.3 → XP_017448873.1  ATP synthase mitochondrial F1 complex assembly factor 1 isoform X2

      Related
      ENSRNOP00000099364.1, ENSRNOT00000158136.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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