cyst cysts [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cystprovided by FlyBase
Official Full Name: cystsprovided by FlyBase
Primary source: FLYBASE:FBgn0032796
Locus tag: Dmel_CG10188
See related: AllianceGenome:FB:FBgn0032796
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10188; Cyst; Dmel\CG10188; Dp114/Cysts; Dp114RhoGEF
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in mitotic cytokinesis, division site positioning. Is active in cleavage furrow rim. Is expressed in adult head; leg; and spermatozoon. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations and retinitis pigmentosa. Orthologous to several human genes including ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18) and ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19502335..19508764, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19502335..19508764, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitotic cytokinesis, division site positioning	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cleavage furrow rim	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain