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    Irc Immune-regulated catalase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ircprovided by FlyBase
    Official Full Name
    Immune-regulated catalaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038465
    Locus tag
    Dmel_CG8913
    See related
    AllianceGenome:FB:FBgn0038465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8913; Dmel\CG8913; HPX2; irc; IRC
    Summary
    Enables peroxidase activity. Involved in cellular oxidant detoxification. Is expressed in adult head; apoptotic amnioserosa; embryonic/larval fat body; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Irc in Genome Data Viewer
    Location:
    89E7-89E8; 3-59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17002875..17007208)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12828597..12832930)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 2A Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3a subunit 1 Neighboring gene uncharacterized protein Neighboring gene Peroxidase Neighboring gene Adenylosuccinate lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Guts and glory: balancing microbes and the immune response. Pal S, et al. Dev Cell, 2005 Jan. PMID 15621522
    2. A direct role for dual oxidase in Drosophila gut immunity. Ha EM, et al. Science, 2005 Nov 4. PMID 16272120
    3. Mechanisms of damage prevention, signalling and repair impact disease tolerance. Prakash A, et al. Proc Biol Sci, 2022 Aug 31. PMID 35975433, Free PMC Article
    4. Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases. Sobrido-Cameán D, et al. Front Cell Neurosci, 2022. PMID 36713781, Free PMC Article
    5. Drosophila as a model for intestinal dysbiosis and chronic inflammatory diseases. Lee KA, et al. Dev Comp Immunol, 2014 Jan. PMID 23685204

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Immune-regulated catalase
    Names
    CG8913-PA
    CG8913-PB
    Irc-PA
    Irc-PB
    immune-regulated catalase
    immune-related catalase
    peroxidase
    NP_001262653.1
    NP_650584.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17002875..17007208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275724.1 → NP_001262653.1  Immune-regulated catalase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961Q3, Q9VEP8
      Conserved Domains (2) summary
      cl14561
      Location:290 → 637
      An_peroxidase_like; Animal heme peroxidases and related proteins
      pfam03098
      Location:151 → 672
      An_peroxidase; Animal haem peroxidase

    2. NM_142327.3 → NP_650584.1  Immune-regulated catalase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961Q3, Q9VEP8
      Related
      FBpp0082814
      Conserved Domains (2) summary
      cl14561
      Location:290 → 637
      An_peroxidase_like; Animal heme peroxidases and related proteins
      pfam03098
      Location:151 → 672
      An_peroxidase; Animal haem peroxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEP8 Q9VEP8

    Gene LinkOut

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