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    LSm1 Like Sm 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSm1provided by FlyBase
    Official Full Name
    Like Sm 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261067
    Locus tag
    Dmel_CG4279
    See related
    AllianceGenome:FB:FBgn0261067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4279; Dmel\CG4279; Lsm1
    Summary
    Predicted to enable mRNA binding activity. Involved in P-body assembly. Predicted to be part of Lsm1-7-Pat1 complex. Predicted to be active in P-body. Orthologous to human LSM1 (LSM1 homolog, mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LSm1 in Genome Data Viewer
    Location:
    57C7-57C7; 2-93 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21169969..21170672, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17057474..17058177, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Tryptophan-CCA 2-4 Neighboring gene Insulator su(Hw) mRNA adaptor Neighboring gene hinge1 Neighboring gene Xeroderma pigmentosum D Neighboring gene Punch Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. Braun JE, et al. EMBO J, 2010 Jul 21. PMID 20543818, Free PMC Article
    2. A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Tritschler F, et al. Mol Cell Biol, 2007 Dec. PMID 17923697, Free PMC Article
    3. Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Tritschler F, et al. Mol Cell Biol, 2008 Nov. PMID 18765641, Free PMC Article
    4. Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation. Li X, et al. PLoS Genet, 2010 Mar 12. PMID 20300654, Free PMC Article
    5. A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Braun JE, et al. Nat Struct Mol Biol, 2012 Dec. PMID 23142987

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in P-body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_611559.1
    • like Sm 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21169969..21170672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137715.4 → NP_611559.1  uncharacterized protein Dmel_CG4279 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6R8, Q9W2K2
      Related
      FBpp0071553
      Conserved Domains (1) summary
      cd01728
      Location:7 → 80
      LSm1; Like-Sm protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2K2 Q9W2K2

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