Spf30 Splicing factor 30 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Spf30provided by FlyBase
Official Full Name: Splicing factor 30provided by FlyBase
Primary source: FLYBASE:FBgn0039977
Locus tag: Dmel_CG17454
See related: AllianceGenome:FB:FBgn0039977
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17454; Dmel\CG17454; SPF30
Summary: Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Orthologous to human SMNDC1 (survival motor neuron domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 80F9-80F9; 3-47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (23715023..23716689)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (23708123..23709789)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

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Preferred Names: splicing factor 30

Names: CG17454-PA; CG17454-PB; Spf30-PA; Spf30-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

23715023..23716689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144529.2 → NP_001138001.1 splicing factor 30, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138001.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RI7

Conserved Domains (2) summary

cd04508
Location:95 → 142

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl00262
Location:22 → 116

TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...
NM_001275307.1 → NP_001262236.1 splicing factor 30, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262236.1

Status: REVIEWED

UniProtKB/TrEMBL

G7H806

Conserved Domains (2) summary

cd04508
Location:82 → 129

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl00262
Location:9 → 103

TroA-like; Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between ...