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    ND-B15 NADH dehydrogenase (ubiquinone) B15 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B15provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B15 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033961
    Locus tag
    Dmel_CG12859
    See related
    AllianceGenome:FB:FBgn0033961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe3B12; CG 12859; CG12859; Dmel\CG12859; dNDUFB4; NB5M; NDUFB4; Q6IDF5
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B15 in Genome Data Viewer
    Location:
    51C2-51C2; 2-72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14756516..14757072)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10644021..10644577)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 6 Neighboring gene uncharacterized protein Neighboring gene aveugle Neighboring gene TRAPP subunit 31 Neighboring gene uncharacterized protein Neighboring gene Sprouty-related protein with EVH-1 domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
    2. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    3. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article
    4. Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. Padavannil A, et al. Elife, 2023 Mar 23. PMID 36952377, Free PMC Article
    5. Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster. Agip AA, et al. Elife, 2023 Jan 9. PMID 36622099, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B15 subunit
    Names
    CG12859-PA
    NADH ubiquinone oxidoreductase B15
    NADH-ubiquinone oxidoreductase B15 subunit
    NADH:ubiquinone oxidoreductase B15 subunit
    ND-B15-PA
    anon-fast-evolving-3B12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14756516..14757072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137141.5 → NP_610985.1  NADH dehydrogenase (ubiquinone) B15 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDF5
      Related
      FBpp0086570
      Conserved Domains (1) summary
      pfam07225
      Location:21 → 111
      NDUF_B4; NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IDF5 Q6IDF5

    Gene LinkOut

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