Hex-C Hexokinase C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hex-Cprovided by FlyBase
Official Full Name: Hexokinase Cprovided by FlyBase
Primary source: FLYBASE:FBgn0001187
Locus tag: Dmel_CG8094
See related: AllianceGenome:FB:FBgn0001187
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8094; CT22069; DM2; Dmel\CG8094; Fk; Hex; HEX; Hex-3; HEX-3; Hex-c; HEX-C; HexC; Hk; HK; HK-C
Summary: Enables glucosamine kinase activity and hexokinase activity. Involved in glucose 6-phosphate metabolic process; glucose catabolic process; and glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Is expressed in adult head; border follicle cell; and spermatozoon. Used to study glucose metabolism disease. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51E7-51E7; 2-74 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15218837..15220329, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11106342..11107834, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.
Title: Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucosamine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hexokinase activity	IEA Inferred from Electronic Annotation more info
enables hexokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mannokinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hexokinase C

Names: CG8094-PA; Hex-C-PA; Hexokinase-3; HexokinaseC; fructokinase; hexokinase; hexokinase-C; hexose kinase

NP_524674.1

EC 2.7.1.-

EC 2.7.1.1

EC 2.7.1.2

EC 2.7.1.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15218837..15220329 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079935.4 → NP_524674.1 hexokinase C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524674.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JYW9, Q9GNE4, Q9GNF4, Q9GTU5

Related

FBpp0086530

Conserved Domains (3) summary

PTZ00107
Location:13 → 454

PTZ00107; hexokinase; Provisional

pfam00349
Location:5 → 200

Hexokinase_1; Hexokinase

pfam03727
Location:207 → 449

Hexokinase_2; Hexokinase