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    IntS3 Integrator 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355010, updated on 27-Dec-2024

    Summary

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    Official Symbol
    IntS3provided by FlyBase
    Official Full Name
    Integrator 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0262117
    Locus tag
    Dmel_CG17665
    See related
    AllianceGenome:FB:FBgn0262117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17665; Dmel\CG17665; Int3; IR23; l(2)IR23; l(2)NC19; l(2)NC28; l(2Rh)IR23; NC19; NC28
    Summary
    Predicted to be involved in snRNA processing. Located in Golgi apparatus. Part of integrator complex. Is active in nucleus. Orthologous to human INTS3 (integrator complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IntS3 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4235779..4242934, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (123284..130439, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribonuclease kappa Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene long non-coding RNA:CR44100

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    2. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
    3. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article
    4. High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster. Dimitri P, et al. Proc Natl Acad Sci U S A, 1997 Jul 22. PMID 9223313, Free PMC Article
    5. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator 3
    Names
    CG17665-PA
    IntS3-PA
    lethal (2) IR23
    lethal (2) NC19
    lethal (2) NC28

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4235779..4242934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042972.2 → NP_001036437.1  integrator 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7PLS7, Q7PLS8, Q8IH20
      Conserved Domains (1) summary
      pfam10189
      Location:247 → 471
      DUF2356; Conserved protein (DUF2356)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7PLS8.1 Q7PLS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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    Research Materials
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