Cyt-b5 Cytochrome b5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyt-b5provided by FlyBase
Official Full Name: Cytochrome b5provided by FlyBase
Primary source: FLYBASE:FBgn0264294
Locus tag: Dmel_CG2140
See related: AllianceGenome:FB:FBgn0264294
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1857; BcDNA:GH02503; BcDNA:RE66521; CG2140; CYT-B5; CYTB5; Dmel\CG2140; dpld; l(2)01857; l(2)k00107
Summary: Predicted to enable heme binding activity. Involved in response to oxidative stress and xenobiotic metabolic process. Located in endomembrane system. Is expressed in several structures, including anlage in statu nascendi; gland; gut section; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A) and CYB5B (cytochrome b5 type B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7533506..7535936)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3421011..3423441)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Regulation of hemocytes in Drosophila requires dappled cytochrome b5
Title: Regulation of hemocytes in Drosophila requires dappled cytochrome b5.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG2140-PA; CG2140-PB; Cyt-b5-PA; Cyt-b5-PB; dappled; lethal (2) k00107

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The following sections contain reference sequences that belong to a specific genome build. Explain