Fa2h Fatty acid 2-hydroxylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fa2hprovided by FlyBase
Official Full Name: Fatty acid 2-hydroxylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0050502
Locus tag: Dmel_CG30502
See related: AllianceGenome:FB:FBgn0050502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1642; CG1645; CG30502; Dmel\CG30502; fa2h; FA2H
Summary: Enables fatty acid 2-hydroxylase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Used to study hereditary spastic paraplegia 35. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7446189..7451553, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3333694..3339058, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

FA2H controls cool temperature sensing through modifying membrane sphingolipids in Drosophila.
Title: FA2H controls cool temperature sensing through modifying membrane sphingolipids in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fatty acid 2-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid 2-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid 2-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables free fatty acid 2-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_610279.3

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The following sections contain reference sequences that belong to a specific genome build. Explain