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    LSm7 Like Sm 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSm7provided by FlyBase
    Official Full Name
    Like Sm 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0261068
    Locus tag
    Dmel_CG13277
    See related
    AllianceGenome:FB:FBgn0261068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH73529; CG13277; Dmel\CG13277; Lsm7; LSM7
    Summary
    Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in embryonic brain; embryonic/larval midgut; larval muscle system; and organism. Orthologous to human LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LSm7 in Genome Data Viewer
    Location:
    36A14-36A14; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16742315..16743100, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16742315..16743100, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Proteasome beta4 subunit Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Bub3 interacting GLEBS and Zinc finger domain protein Neighboring gene yellow-b Neighboring gene pickpocket 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide RNAi screen reveals that mRNA decapping restricts bunyaviral replication by limiting the pools of Dcp2-accessible targets for cap-snatching. Hopkins KC, et al. Genes Dev, 2013 Jul 1. PMID 23824541, Free PMC Article
    2. A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Tritschler F, et al. Mol Cell Biol, 2007 Dec. PMID 17923697, Free PMC Article
    3. Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Tritschler F, et al. Mol Cell Biol, 2008 Nov. PMID 18765641, Free PMC Article
    4. A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Braun JE, et al. Nat Struct Mol Biol, 2012 Dec. PMID 23142987
    5. HPat provides a link between deadenylation and decapping in metazoa. Haas G, et al. J Cell Biol, 2010 Apr 19. PMID 20404111, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001246045.1
    • like Sm 7, isoform B
    NP_001285985.1
    • like Sm 7, isoform C
    NP_609807.1
    • like Sm 7, isoform A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16742315..16743100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299056.1 → NP_001285985.1  uncharacterized protein Dmel_CG13277 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1PFP9, Q9VJI7
      Conserved Domains (1) summary
      cd01729
      Location:18 → 107
      LSm7; Like-Sm protein 7

    2. NM_135963.4 → NP_609807.1  uncharacterized protein Dmel_CG13277 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1PFP9, Q9VJI7
      Related
      FBpp0080488
      Conserved Domains (1) summary
      cd01729
      Location:18 → 107
      LSm7; Like-Sm protein 7

    3. NM_001259116.3 → NP_001246045.1  uncharacterized protein Dmel_CG13277 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1PFP9, Q9VJI7
      Conserved Domains (1) summary
      cd01729
      Location:18 → 107
      LSm7; Like-Sm protein 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJI7 Q9VJI7

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