Kif20b kinesin family member 20B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif20bprovided by RGD
Official Full Name: kinesin family member 20Bprovided by RGD
Primary source: RGD:1308497
See related: EnsemblRapid:ENSRNOG00000018929 AllianceGenome:RGD:1308497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mphosph1
Summary: Predicted to enable several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including positive regulation of mitotic cytokinetic process; positive regulation of neuron migration; and protein localization to microtubule. Predicted to act upstream of or within several processes, including neural tube closure; regulation of establishment of cell polarity; and regulation of neuron migration. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Orthologous to human KIF20B (kinesin family member 20B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 106.3), Testes (RPKM 89.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241840898..241896451)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (232428293..232483798)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (253220038..253275523)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in contractile ring	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF20B

Names: M-phase phosphoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107609.2 → NP_001101079.2 kinesin-like protein KIF20B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K7C2, D3ZX13

Related

ENSRNOP00000074144.2, ENSRNOT00000085880.3

Conserved Domains (7) summary

COG1340
Location:1046 → 1335

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01368
Location:58 → 476

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:64 → 478

Kinesin; Kinesin motor domain

pfam00261
Location:1249 → 1477

Tropomyosin; Tropomyosin

pfam10211
Location:1225 → 1300

Ax_dynein_light; Axonemal dynein light chain

pfam15035
Location:1095 → 1246

Rootletin; Ciliary rootlet component, centrosome cohesion

cl23887
Location:1178 → 1330

DUF4349; Domain of unknown function (DUF4349)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

241840898..241896451

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231284.4 → XP_006231346.1 kinesin-like protein KIF20B isoform X3

UniProtKB/TrEMBL

D3ZX13

Conserved Domains (7) summary

COG1340
Location:1008 → 1297

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01368
Location:58 → 476

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:64 → 478

Kinesin; Kinesin motor domain

pfam00261
Location:1211 → 1439

Tropomyosin; Tropomyosin

pfam10211
Location:1187 → 1262

Ax_dynein_light; Axonemal dynein light chain

pfam15035
Location:1057 → 1208

Rootletin; Ciliary rootlet component, centrosome cohesion

cl23887
Location:1140 → 1292

DUF4349; Domain of unknown function (DUF4349)
XM_006231285.4 → XP_006231347.1 kinesin-like protein KIF20B isoform X4

UniProtKB/TrEMBL

D3ZX13

Related

ENSRNOP00000051636.3, ENSRNOT00000054753.5

Conserved Domains (7) summary

COG1340
Location:1008 → 1297

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01368
Location:58 → 476

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:64 → 478

Kinesin; Kinesin motor domain

pfam00261
Location:1211 → 1439

Tropomyosin; Tropomyosin

pfam10211
Location:1187 → 1262

Ax_dynein_light; Axonemal dynein light chain

pfam15035
Location:1057 → 1208

Rootletin; Ciliary rootlet component, centrosome cohesion

cl23887
Location:1140 → 1292

DUF4349; Domain of unknown function (DUF4349)
XM_006231281.4 → XP_006231343.1 kinesin-like protein KIF20B isoform X1

See identical proteins and their annotated locations for XP_006231343.1

UniProtKB/TrEMBL

A0A8I6AFD4, D3ZX13

Related

ENSRNOP00000091324.1, ENSRNOT00000099249.2

Conserved Domains (7) summary

COG1340
Location:1048 → 1337

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd01368
Location:58 → 476

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:64 → 478

Kinesin; Kinesin motor domain

pfam00261
Location:1251 → 1479

Tropomyosin; Tropomyosin

pfam10211
Location:1227 → 1302

Ax_dynein_light; Axonemal dynein light chain

pfam15035
Location:1097 → 1248

Rootletin; Ciliary rootlet component, centrosome cohesion

cl23887
Location:1180 → 1332

DUF4349; Domain of unknown function (DUF4349)
XM_006231283.4 → XP_006231345.1 kinesin-like protein KIF20B isoform X2

UniProtKB/TrEMBL

D3ZX13

Conserved Domains (4) summary

PLN02939
Location:1287 → 1546

PLN02939; transferase, transferring glycosyl groups

COG1196
Location:628 → 1403

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01368
Location:58 → 476

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

cd21786
Location:599 → 647

RBD_KIF20B; RAB6 binding domain (RBD) found in kinesin-like protein KIF20B, and similar proteins
XM_006231286.2 → XP_006231348.1 kinesin-like protein KIF20B isoform X5

UniProtKB/TrEMBL

D3ZX13

Conserved Domains (4) summary

COG1340
Location:858 → 1147

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cl22853
Location:70 → 286

Motor_domain; Myosin and Kinesin motor domain

pfam10211
Location:1037 → 1112

Ax_dynein_light; Axonemal dynein light chain

cl23887
Location:990 → 1142

DUF4349; Domain of unknown function (DUF4349)