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    CG31871 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31871provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051871
    Locus tag
    Dmel_CG31871
    See related
    AllianceGenome:FB:FBgn0051871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17087; CG17099; Dmel\CG31871
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Is expressed in several structures, including anal pad primordium; anlage in statu nascendi; dorsal ectoderm anlage; embryonic anal pad; and gut section. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31871 in Genome Data Viewer
    Location:
    32A2-32A3; 2-43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10662081..10671487)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10662081..10671487)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45692 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. van Eyk CL, et al. Hum Mol Genet, 2011 Jul 15. PMID 21518731, Free PMC Article
    2. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    3. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article
    4. Global analysis of patterns of gene expression during Drosophila embryogenesis. Tomancak P, et al. Genome Biol, 2007. PMID 17645804, Free PMC Article
    5. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. Parkhitko AA, et al. PLoS Genet, 2021 Feb. PMID 33591981, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31871-PA
    NP_723607.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10662081..10671487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164939.2 → NP_723607.1  uncharacterized protein Dmel_CG31871 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKS5
      Related
      FBpp0079693
      Conserved Domains (3) summary
      COG0596
      Location:93 → 436
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam04083
      Location:79 → 133
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:115 → 281
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKS5 Q9VKS5

    Gene LinkOut

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