U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG18301 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34451, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG18301provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032265
    Locus tag
    Dmel_CG18301
    See related
    AllianceGenome:FB:FBgn0032265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG18301
    Summary
    Enables serine hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in lipid droplet. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG18301 in Genome Data Viewer
    Location:
    31F5-31F5; 2-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10531821..10533647)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10531821..10533647)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat 47 Neighboring gene Lipase 4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44618

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila. Fleck SA, et al. Elife, 2024 Jan 19. PMID 38240746, Free PMC Article
    2. The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects. Lobell AS, et al. G3 (Bethesda), 2017 Jul 5. PMID 28550012, Free PMC Article
    3. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    4. Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease. Vartiainen S, et al. Dis Model Mech, 2014 Jun. PMID 24812436, Free PMC Article
    5. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG18301-PA
    NP_609419.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10531821..10533647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135575.2 → NP_609419.1  uncharacterized protein Dmel_CG18301 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4Z5, Q9VKT8
      Related
      FBpp0079683
      Conserved Domains (3) summary
      PLN02872
      Location:48 → 407
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:46 → 100
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:82 → 225
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKT8 Q9VKT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools