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    Schip1 Schwannomin interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Schip1provided by FlyBase
    Official Full Name
    Schwannomin interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032221
    Locus tag
    Dmel_CG5375
    See related
    AllianceGenome:FB:FBgn0032221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5375; Dmel\CG5375
    Summary
    Involved in negative regulation of growth; positive regulation of hippo signaling; and positive regulation of protein serine/threonine kinase activity. Located in adherens junction and apical plasma membrane. Is expressed in eye disc and wing disc. Orthologous to human IQCJ-SCHIP1 (IQCJ-SCHIP1 readthrough) and SCHIP1 (schwannomin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Schip1 in Genome Data Viewer
    Location:
    31D8-31D9; 2-41 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10328200..10331116, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10328200..10331116, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonucleoside diphosphate reductase large subunit Neighboring gene Cytochrome c oxidase assembly factor 10 Neighboring gene GATAd

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling. Chung HL, et al. Dev Cell, 2016 Mar 7. PMID 26954546
    2. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schip1 directly links Ex to Hpo signaling by recruiting Tao-1
      Title: Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    schwannomin interacting protein 1
    Names
    CG5375-PB
    CG5375-PC
    Schip1 ortholog
    Schip1-PB
    Schip1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10328200..10331116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347808.1 → NP_001334735.1  schwannomin interacting protein 1, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1W5PX37

    2. NM_001103669.2 → NP_001097139.1  schwannomin interacting protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYY6
      Conserved Domains (1) summary
      pfam10148
      Location:374 → 602
      SCHIP-1; Schwannomin-interacting protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1W5PX37 A0A1W5PX37
    A8DYY6.1 A8DYY6

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