Replication interactions
Interaction |
Pubs |
HIV-1 infectivity involves C5AR1 in complex with CCR5 on THP-1 and monocyte-derived macrophages as shown through decreased CCR5-tropic provirus genomic integration in the presence of neutralizing C5aR1 antibody or siRNA or hC5a |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes |
PubMed
|
Nef
|
nef
|
Stable expression of HIV-1 Nef induces the upregulated expression of CD88 (complement receptor C5a) |
PubMed
|
Vpr
|
vpr
|
A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of complement component 5a receptor 1 (C5AR1) expression by HIV-1 Vpr in Vpr transduced macrophages |
PubMed
|
Go to the HIV-1, Human Interaction Database