tai taiman [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: taiprovided by FlyBase
Official Full Name: taimanprovided by FlyBase
Primary source: FLYBASE:FBgn0041092
Locus tag: Dmel_CG13109
See related: AllianceGenome:FB:FBgn0041092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 58/2; bs13g05.y1; CG13109; CG18494; DAIB1; Dmel\CG13109; DmTai; DmTaiman; EP(2)2630; l(2)01351; l(2)k05802; l(2)k05809; NEST:bs13g05; Tai; TAI; Taiman
Summary: Enables nuclear receptor binding activity; nuclear receptor coactivator activity; and transcription coactivator binding activity. Involved in several processes, including border follicle cell migration; germ-line stem-cell niche homeostasis; and positive regulation of border follicle cell migration. Located in nucleus. Is expressed in several structures, including follicle cell; olfactory receptor neurons; somatic cell of testis; and spermatozoon. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; obesity; and prostate adenocarcinoma. Orthologous to human NCOA1 (nuclear receptor coactivator 1); NCOA2 (nuclear receptor coactivator 2); and NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 30A2-30A6; 2-35 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9166778..9250211)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9166778..9250211)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tai expression transforms sessile pupal wing cells into an invasive mass that penetrates the adjacent thorax during a period of high 20-hydroxyecdysone.
Title: The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0434 (e-PCR)
- UniSTS:59412

Dm0247 (e-PCR)
- UniSTS:75467

Dm2226 (e-PCR)
- UniSTS:41448

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 9194175-9194262 mobile_element_type = transposon:INE-1{}5737

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: taiman

Names: CG13109-PC; CG13109-PD; CG13109-PE; CG13109-PF; CG13109-PG; CG13109-PH; drosophila amplified in breast cancer-1; tai-PC; tai-PD; tai-PE; tai-PF; tai-PG; tai-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9166778..9250211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259020.2 → NP_001245949.1 taiman, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245949.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND53, Q9GS19

Conserved Domains (3) summary

smart00091
Location:377 → 442

PAS; PAS domain

cd00083
Location:235 → 286

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14598
Location:591 → 711

PAS_11; PAS domain
NM_078797.4 → NP_523521.3 taiman, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523521.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9GS19, Q9VLD9

Conserved Domains (3) summary

smart00091
Location:377 → 442

PAS; PAS domain

cd00083
Location:235 → 286

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14598
Location:591 → 711

PAS_11; PAS domain
NM_001273351.1 → NP_001260280.1 taiman, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260280.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRG5, Q9GS19

Conserved Domains (3) summary

smart00091
Location:377 → 442

PAS; PAS domain

cd00083
Location:235 → 286

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14598
Location:591 → 711

PAS_11; PAS domain
NM_001201819.2 → NP_001188748.1 taiman, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188748.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRG5, Q9GS19

Conserved Domains (3) summary

smart00091
Location:377 → 442

PAS; PAS domain

cd00083
Location:235 → 286

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14598
Location:591 → 711

PAS_11; PAS domain
NM_001201818.1 → NP_001188747.1 taiman, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188747.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRJ8, Q9GS19

Conserved Domains (3) summary

smart00091
Location:377 → 442

PAS; PAS domain

cd00083
Location:235 → 286

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14598
Location:591 → 711

PAS_11; PAS domain
NM_001201817.1 → NP_001188746.1 taiman, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188746.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GS19, Q9VLD9

Conserved Domains (3) summary

smart00091
Location:377 → 442

PAS; PAS domain

cd00083
Location:235 → 286

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14598
Location:591 → 711

PAS_11; PAS domain