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    Msl2 MSL complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315959, updated on 27-Nov-2024

    Summary

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    Symbol
    Msl2provided by RGD
    Full Name
    MSL complex subunit 2provided by RGD
    Primary source
    RGD:1310355
    See related
    EnsemblRapid:ENSRNOG00000023021 AllianceGenome:RGD:1310355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Msl2l1; RGD1310355
    Summary
    Predicted to enable histone H2B ubiquitin ligase activity and promoter-enhancer loop anchoring activity. Predicted to be involved in DNA damage response; protein monoubiquitination; and regulation of gene expression. Predicted to be part of MSL complex. Predicted to be active in chromatin and nucleus. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 172.1), Spleen (RPKM 150.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msl2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (110555579..110642096)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (101676605..101702818)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (109456097..109480143)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19, pseudogene 8 Neighboring gene propionyl-CoA carboxylase subunit beta Neighboring gene protein phosphatase 2, regulatory subunit B'', alpha Neighboring gene uncharacterized LOC134480092 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2B ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-enhancer loop anchoring activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MSL2
    Names
    male-specific lethal 2 homolog
    male-specific lethal 2-like 1
    NP_001388814.1
    XP_038938512.1
    XP_038938513.1
    XP_063121668.1
    XP_063121669.1
    XP_063121670.1
    XP_063121671.1
    XP_063121672.1
    XP_063121673.1
    XP_063121674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401885.1 → NP_001388814.1  E3 ubiquitin-protein ligase MSL2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2G4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      110555579..110642096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082584.2 → XP_038938512.1  E3 ubiquitin-protein ligase MSL2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AT15
      Conserved Domains (3) summary
      TIGR03551
      Location:203 → 245
      F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
      pfam16682
      Location:414 → 468
      MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
      pfam16685
      Location:3 → 70
      zf-RING_10; zinc RING finger of MSL2

    2. XM_063265600.1 → XP_063121670.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    3. XM_063265601.1 → XP_063121671.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    4. XM_063265603.1 → XP_063121673.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    5. XM_063265604.1 → XP_063121674.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    6. XM_063265598.1 → XP_063121668.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    7. XM_063265599.1 → XP_063121669.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    8. XM_063265602.1 → XP_063121672.1  E3 ubiquitin-protein ligase MSL2 isoform X1

    9. XM_039082585.2 → XP_038938513.1  E3 ubiquitin-protein ligase MSL2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AT15
      Related
      ENSRNOP00000097482.1, ENSRNOT00000108984.2
      Conserved Domains (3) summary
      TIGR03551
      Location:170 → 212
      F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
      pfam16682
      Location:381 → 435
      MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
      cl17238
      Location:1 → 37
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version

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