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    Aatf Apoptosis antagonizing transcription factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33943, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Aatfprovided by FlyBase
    Official Full Name
    Apoptosis antagonizing transcription factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031851
    Locus tag
    Dmel_CG11188
    See related
    AllianceGenome:FB:FBgn0031851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AATF; anon-WO0118547.190; CG11188; Che-1; Dmel\CG11188; nutmeg
    Summary
    Involved in negative regulation of programmed cell death and oogenesis. Located in nucleolus. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and larval muscle cell. Used to study chromosome 17q12 deletion syndrome. Orthologous to human AATF (apoptosis antagonizing transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aatf in Genome Data Viewer
    Location:
    27A1-27A1; 2-22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6717625..6719389)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6717625..6719389)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Thrombospondin Neighboring gene Adipokinetic hormone receptor Neighboring gene homer Neighboring gene Liprin-alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. Bharucha KN, et al. J Exp Biol, 2008 Oct. PMID 18805809, Free PMC Article
    2. Dual lipolytic control of body fat storage and mobilization in Drosophila. Grönke S, et al. PLoS Biol, 2007 Jun. PMID 17488184, Free PMC Article
    3. A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis. Jagut M, et al. G3 (Bethesda), 2013 Mar. PMID 23450845, Free PMC Article
    4. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article
    5. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis antagonizing transcription factor
    Names
    Aatf-PA
    CG11188-PA
    apoptosis antagonizing transcription factor ortholog
    nutmeg

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6717625..6719389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135222.3 → NP_609066.1  apoptosis antagonizing transcription factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609066.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM95
      Related
      FBpp0078929
      Conserved Domains (2) summary
      pfam08164
      Location:405 → 487
      TRAUB; Apoptosis-antagonizing transcription factor, C-terminal
      pfam13339
      Location:211 → 337
      AATF-Che1; Apoptosis antagonizing transcription factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM95.1 Q9VM95

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