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    CG11034 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11034provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031741
    Locus tag
    Dmel_CG11034
    See related
    AllianceGenome:FB:FBgn0031741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11034
    Summary
    Enables dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; asthma; autosomal dominant intellectual developmental disorder 33; motor neuron disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including DPP4 (dipeptidyl peptidase 4); DPP10 (dipeptidyl peptidase like 10); and DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11034 in Genome Data Viewer
    Location:
    25F5-25F5; 2-17 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5805395..5809063)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5805395..5809063)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44575 Neighboring gene long non-coding RNA:CR44576

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara CJ, et al. J Insect Sci, 2005 Nov 2. PMID 17119608, Free PMC Article
    2. Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation. Sieglitz F, et al. Sci Signal, 2013 Nov 5. PMID 24194583
    3. Genome-wide transcription analysis of clinal genetic variation in Drosophila. Chen Y, et al. PLoS One, 2012. PMID 22514645, Free PMC Article
    4. The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity. Vichas A, et al. J Cell Biol, 2015 Dec 7. PMID 26644515, Free PMC Article
    5. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Garrido-Maraver J, et al. Biol Open, 2020 Jan 14. PMID 31822473, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11034-PB
    CG11034-PC
    CG11034-PD
    NP_001285637.1
    NP_001285638.1
    NP_608961.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5805395..5809063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298709.1 → NP_001285638.1  uncharacterized protein Dmel_CG11034, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMM2
      Conserved Domains (2) summary
      pfam00326
      Location:538 → 745
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:103 → 457
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_001298708.1 → NP_001285637.1  uncharacterized protein Dmel_CG11034, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9G3

    3. NM_135117.3 → NP_608961.2  uncharacterized protein Dmel_CG11034, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608961.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMM2
      Conserved Domains (2) summary
      pfam00326
      Location:538 → 745
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:103 → 457
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMM2 Q9VMM2
    X2J9G3 X2J9G3

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