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    Pgant5 Polypeptide N-Acetylgalactosaminyltransferase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant5provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0031681
    Locus tag
    Dmel_CG31651
    See related
    AllianceGenome:FB:FBgn0031681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31651; CG9152; Dmel\CG31651; l(2)e02157; pgant5; PGANT5; pgnat5
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Located in endomembrane system. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval midgut primordium; gut section; and imaginal disc. Orthologous to human GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant5 in Genome Data Viewer
    Location:
    25C4-25C6; 2-15 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5072170..5093592, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5072170..5093592, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene quick-to-court Neighboring gene antisense RNA:CR45305 Neighboring gene mir-2495 stem loop Neighboring gene Ribosomal protein L37A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa A subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs. Gerken TA, et al. Glycobiology, 2008 Nov. PMID 18669915, Free PMC Article
    2. Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila. Frenkel-Pinter M, et al. Neurobiol Aging, 2017 Aug. PMID 28552182
    3. In vivo models of mucin biosynthesis and function. Syed ZA, et al. Adv Drug Deliv Rev, 2022 May. PMID 35278522, Free PMC Article
    4. Insights from Drosophila melanogaster model of Alzheimer's disease. Tue NT, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585881
    5. Influence of the quick-to-court gene deletion on courtship behaviour of Drosophila melanogaster. G Belkina E, et al. J Genet, 2021. PMID 34238777

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 5
    Names
    CG31651-PA
    CG31651-PB
    Pgant5-PA
    Pgant5-PB
    lethal (2) e02157
    polypeptide GalNAc transferase 5
    NP_001036338.1
    NP_608906.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5072170..5093592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042873.2 → NP_001036338.1  polypeptide N-Acetylgalactosaminyltransferase 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6WV17
      Conserved Domains (2) summary
      cd02510
      Location:190 → 490
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:503 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_135062.4 → NP_608906.2  polypeptide N-Acetylgalactosaminyltransferase 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608906.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8T2, Q6WV17, Q95T43, Q9VMU3
      Related
      FBpp0078663
      Conserved Domains (2) summary
      cd02510
      Location:190 → 490
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:503 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WV17.2 Q6WV17

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