CNOT8 CCR4-NOT transcription complex subunit 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CNOT8provided by HGNC
Official Full Name: CCR4-NOT transcription complex subunit 8provided by HGNC
Primary source: HGNC:HGNC:9207
See related: Ensembl:ENSG00000155508 MIM:603731; AllianceGenome:HGNC:9207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAF1; POP2; CALIF; Caf1b; hCAF1
Summary: Enables poly(A)-specific ribonuclease activity. Involved in miRNA-mediated gene silencing by mRNA destabilization and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q33.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (154858249..154876792)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (155392211..155410754)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (154237809..154256352)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
Title: A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
Title: Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module.
Title: The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.
CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC.
Title: CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.
The loss of CAF-1 p48 subunit causes a strong defect in packaging DNA into nucleosomes.
Title: Human CAF-1-dependent nucleosome assembly in a defined system.
show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets
Title: The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Title: The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
Title: The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.
N-terminus played a role in modulating hCaf1 activity, stability and aggregation
Title: The N-terminus modulates human Caf1 activity, structural stability and aggregation.
Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA.
Title: Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A004P22 (e-PCR)
- UniSTS:61522

SGC32815 (e-PCR)
- UniSTS:45490

RH65257 (e-PCR)
- UniSTS:46524

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IDA Inferred from Direct Assay more info	PubMed
part_of CCR4-NOT complex	NAS Non-traceable Author Statement more info	PubMed
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 8

Names: CAF1-like protein; CAF2; CALIFp; CCR4-associated factor 8; PGK promoter directed over production

NP_001288002.1

EC 3.1.13.4

NP_001288003.1

EC 3.1.13.4

NP_001288004.1

EC 3.1.13.4

NP_001288006.1

EC 3.1.13.4

NP_001288009.1

EC 3.1.13.4

NP_001288011.1

EC 3.1.13.4

NP_001288012.1

EC 3.1.13.4

NP_001288015.1

EC 3.1.13.4

NP_004770.4

EC 3.1.13.4

XP_016865539.1

EC 3.1.13.4

XP_016865540.1

EC 3.1.13.4

XP_016865543.1

EC 3.1.13.4

XP_016865544.1

EC 3.1.13.4

XP_016865545.1

EC 3.1.13.4

XP_047273836.1

EC 3.1.13.4

XP_047273837.1

EC 3.1.13.4

XP_047273838.1

EC 3.1.13.4

XP_047273839.1

EC 3.1.13.4

XP_047273840.1

EC 3.1.13.4

XP_047273841.1

EC 3.1.13.4

XP_047273842.1

EC 3.1.13.4

XP_047273843.1

EC 3.1.13.4

XP_047273844.1

EC 3.1.13.4

XP_047273845.1

EC 3.1.13.4

XP_047273846.1

EC 3.1.13.4

XP_047273847.1

EC 3.1.13.4

XP_047273848.1

EC 3.1.13.4

XP_047273849.1

EC 3.1.13.4

XP_054209778.1

EC 3.1.13.4

XP_054209779.1

EC 3.1.13.4

XP_054209780.1

EC 3.1.13.4

XP_054209781.1

EC 3.1.13.4

XP_054209782.1

EC 3.1.13.4

XP_054209783.1

EC 3.1.13.4

XP_054209784.1

EC 3.1.13.4

XP_054209785.1

EC 3.1.13.4

XP_054209786.1

EC 3.1.13.4

XP_054209787.1

EC 3.1.13.4

XP_054209788.1

EC 3.1.13.4

XP_054209789.1

EC 3.1.13.4

XP_054209790.1

EC 3.1.13.4

XP_054209791.1

EC 3.1.13.4

XP_054209792.1

EC 3.1.13.4

XP_054209793.1

EC 3.1.13.4

XP_054209794.1

EC 3.1.13.4

XP_054209795.1

EC 3.1.13.4

XP_054209796.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301073.2 → NP_001288002.1 CCR4-NOT transcription complex subunit 8 isoform 1

See identical proteins and their annotated locations for NP_001288002.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and encode the same isoform (1), compared to variant 1.

Source sequence(s)

AK025358, AL122045

Consensus CDS

CCDS4329.1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9

Related

ENSP00000285896.6, ENST00000285896.11

Conserved Domains (1) summary

cl23804
Location:1 → 263

CAF1; CAF1 family ribonuclease
NM_001301074.2 → NP_001288003.1 CCR4-NOT transcription complex subunit 8 isoform 2

See identical proteins and their annotated locations for NP_001288003.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK303775, AK314317, AL122045

Consensus CDS

CCDS75361.1

UniProtKB/TrEMBL

E5RIL2

Related

ENSP00000430833.1, ENST00000519404.5

Conserved Domains (1) summary

cl23804
Location:1 → 209

CAF1; CAF1 family ribonuclease
NM_001301075.2 → NP_001288004.1 CCR4-NOT transcription complex subunit 8 isoform 3

See identical proteins and their annotated locations for NP_001288004.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.

Source sequence(s)

AK297381, AK314317, AL122045

Consensus CDS

CCDS78074.1

UniProtKB/Swiss-Prot

Q9UFF9

Conserved Domains (1) summary

cl23804
Location:1 → 157

CAF1; CAF1 family ribonuclease
NM_001301077.2 → NP_001288006.1 CCR4-NOT transcription complex subunit 8 isoform 3

See identical proteins and their annotated locations for NP_001288006.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.

Source sequence(s)

AK309359, AL122045, DC387160

Consensus CDS

CCDS78074.1

UniProtKB/Swiss-Prot

Q9UFF9

Related

ENSP00000429882.1, ENST00000521583.5

Conserved Domains (1) summary

cl23804
Location:1 → 157

CAF1; CAF1 family ribonuclease
NM_001301080.2 → NP_001288009.1 CCR4-NOT transcription complex subunit 8 isoform 3

See identical proteins and their annotated locations for NP_001288009.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) has an alternate splice site and lacks two internal exons in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.

Source sequence(s)

AK315864, AL122045

Consensus CDS

CCDS78074.1

UniProtKB/Swiss-Prot

Q9UFF9

Related

ENSP00000428305.1, ENST00000520671.5

Conserved Domains (1) summary

cl23804
Location:1 → 157

CAF1; CAF1 family ribonuclease
NM_001301082.1 → NP_001288011.1 CCR4-NOT transcription complex subunit 8 isoform 3

See identical proteins and their annotated locations for NP_001288011.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.

Source sequence(s)

AK316221, AL122045

Consensus CDS

CCDS78074.1

UniProtKB/Swiss-Prot

Q9UFF9

Related

ENSP00000431034.1, ENST00000521450.5

Conserved Domains (1) summary

cl23804
Location:1 → 157

CAF1; CAF1 family ribonuclease
NM_001301083.1 → NP_001288012.1 CCR4-NOT transcription complex subunit 8 isoform 3

See identical proteins and their annotated locations for NP_001288012.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) has an alternate 5' UTR exon and also lacks two consecutive internal exons, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.

Source sequence(s)

AK316269, AL122045, AL520837

Consensus CDS

CCDS78074.1

UniProtKB/Swiss-Prot

Q9UFF9

Related

ENSP00000428565.1, ENST00000523698.5

Conserved Domains (1) summary

cl23804
Location:1 → 157

CAF1; CAF1 family ribonuclease
NM_001301086.2 → NP_001288015.1 CCR4-NOT transcription complex subunit 8 isoform 4

See identical proteins and their annotated locations for NP_001288015.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) has an alternate splice site and lacks two internal exons in the 5' region, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to variant 1.

Source sequence(s)

AK315864, AK316055, AL122045

Consensus CDS

CCDS78075.1

UniProtKB/TrEMBL

B7Z9U0

Related

ENSP00000429576.1, ENST00000524105.5

Conserved Domains (1) summary

cl23804
Location:1 → 99

CAF1; CAF1 family ribonuclease
NM_004779.6 → NP_004770.4 CCR4-NOT transcription complex subunit 8 isoform 1

See identical proteins and their annotated locations for NP_004770.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform 1.

Source sequence(s)

AK314317, AL122045

Consensus CDS

CCDS4329.1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9

Related

ENSP00000384747.2, ENST00000403027.6

Conserved Domains (1) summary

cl23804
Location:1 → 263

CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

154858249..154876792

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417891.1 → XP_047273847.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_047417890.1 → XP_047273846.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_047417892.1 → XP_047273848.1 CCR4-NOT transcription complex subunit 8 isoform X4

UniProtKB/TrEMBL

B7Z9U0
XM_047417881.1 → XP_047273837.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_047417882.1 → XP_047273838.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_047417880.1 → XP_047273836.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_047417885.1 → XP_047273841.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_017010051.2 → XP_016865540.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9

Conserved Domains (1) summary

cl23804
Location:1 → 263

CAF1; CAF1 family ribonuclease
XM_017010055.3 → XP_016865544.1 CCR4-NOT transcription complex subunit 8 isoform X2

UniProtKB/TrEMBL

E5RIL2

Related

ENSP00000429394.1, ENST00000518775.5

Conserved Domains (1) summary

cl23804
Location:1 → 209

CAF1; CAF1 family ribonuclease
XM_047417884.1 → XP_047273840.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_047417889.1 → XP_047273845.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_017010050.2 → XP_016865539.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9

Conserved Domains (1) summary

cl23804
Location:1 → 263

CAF1; CAF1 family ribonuclease
XM_017010054.3 → XP_016865543.1 CCR4-NOT transcription complex subunit 8 isoform X2

UniProtKB/TrEMBL

E5RIL2

Conserved Domains (1) summary

cl23804
Location:1 → 209

CAF1; CAF1 family ribonuclease
XM_047417888.1 → XP_047273844.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_047417883.1 → XP_047273839.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_047417893.1 → XP_047273849.1 CCR4-NOT transcription complex subunit 8 isoform X5

UniProtKB/TrEMBL

E5RHL9

Related

ENSP00000428576.1, ENST00000522644.5
XM_017010056.2 → XP_016865545.1 CCR4-NOT transcription complex subunit 8 isoform X2

UniProtKB/TrEMBL

E5RIL2

Conserved Domains (1) summary

cl23804
Location:1 → 209

CAF1; CAF1 family ribonuclease
XM_047417886.1 → XP_047273842.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_047417887.1 → XP_047273843.1 CCR4-NOT transcription complex subunit 8 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

155392211..155410754

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353819.1 → XP_054209794.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_054353806.1 → XP_054209781.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_054353807.1 → XP_054209782.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_054353818.1 → XP_054209793.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_054353820.1 → XP_054209795.1 CCR4-NOT transcription complex subunit 8 isoform X4

UniProtKB/TrEMBL

B7Z9U0
XM_054353808.1 → XP_054209783.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_054353804.1 → XP_054209779.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_054353810.1 → XP_054209785.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_054353811.1 → XP_054209786.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_054353803.1 → XP_054209778.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_054353809.1 → XP_054209784.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_054353817.1 → XP_054209792.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_054353816.1 → XP_054209791.1 CCR4-NOT transcription complex subunit 8 isoform X3
XM_054353813.1 → XP_054209788.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_054353805.1 → XP_054209780.1 CCR4-NOT transcription complex subunit 8 isoform X1

UniProtKB/Swiss-Prot

B0AZS3, B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1, Q9UFF9
XM_054353821.1 → XP_054209796.1 CCR4-NOT transcription complex subunit 8 isoform X5

UniProtKB/TrEMBL

E5RHL9
XM_054353814.1 → XP_054209789.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_054353812.1 → XP_054209787.1 CCR4-NOT transcription complex subunit 8 isoform X2
XM_054353815.1 → XP_054209790.1 CCR4-NOT transcription complex subunit 8 isoform X2