U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG4887 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33304, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG4887provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031318
    Locus tag
    Dmel_CG4887
    See related
    AllianceGenome:FB:FBgn0031318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4887; Dmel\CG4887
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in adult brain; adult pars intercerebralis; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to several human genes including RBM10 (RNA binding motif protein 10) and RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG4887 in Genome Data Viewer
    Location:
    21F2-21F2; 2-2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1173009..1177589)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1173009..1177589)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phospholipase A2 activator protein Neighboring gene uncharacterized protein Neighboring gene charon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-guanine transglycosylase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Mensch J, et al. Genome Biol Evol, 2013. PMID 24171912, Free PMC Article
    2. Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. Andersen DS, et al. Mol Cell Biol, 2010 Oct. PMID 20679484, Free PMC Article
    3. The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila. Kockmann T, et al. Genome Biol, 2013 Feb 25. PMID 23442797, Free PMC Article
    4. A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Thomae AW, et al. Dev Cell, 2013 Nov 25. PMID 24239514
    5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG4887-PA
    CG4887-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1173009..1177589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272930.1 → NP_001259859.1  uncharacterized protein Dmel_CG4887, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZM4, Q9VPY4
      Conserved Domains (7) summary
      smart00547
      Location:341 → 364
      ZnF_RBZ; Zinc finger domain
      cd12313
      Location:387 → 473
      RRM1_RRM2_RBM5_like; RNA recognition motif 1 and 2 in RNA-binding protein 5 (RBM5) and similar proteins
      sd00025
      Location:342 → 361
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01585
      Location:935 → 979
      G-patch; G-patch domain
      pfam08648
      Location:115 → 196
      DUF1777; Protein of unknown function (DUF1777)
      cd16162
      Location:623 → 678
      OCRE_RBM5_like; OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins
      cl17169
      Location:255 → 335
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_134738.4 → NP_608582.2  uncharacterized protein Dmel_CG4887, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608582.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZM4, Q9VPY4
      Related
      FBpp0077631
      Conserved Domains (7) summary
      smart00547
      Location:341 → 364
      ZnF_RBZ; Zinc finger domain
      cd12313
      Location:387 → 473
      RRM1_RRM2_RBM5_like; RNA recognition motif 1 and 2 in RNA-binding protein 5 (RBM5) and similar proteins
      sd00025
      Location:342 → 361
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam01585
      Location:935 → 979
      G-patch; G-patch domain
      pfam08648
      Location:115 → 196
      DUF1777; Protein of unknown function (DUF1777)
      cd16162
      Location:623 → 678
      OCRE_RBM5_like; OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins
      cl17169
      Location:255 → 335
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZM4 Q8SZM4
    Q9VPY4 Q9VPY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous