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    CG5254 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5254provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040383
    Locus tag
    Dmel_CG5254
    See related
    AllianceGenome:FB:FBgn0040383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT16777; Dmel\CG5254; EG:BACR19J1.2
    Summary
    Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5254 in Genome Data Viewer
    Location:
    1C3-1C4; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (750347..758719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (644380..652752)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene sidekick Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44965 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Valsecchi CIK, et al. Nat Commun, 2018 Sep 7. PMID 30194291, Free PMC Article
    2. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    3. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
    4. Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster. Parker GA, et al. G3 (Bethesda), 2020 Mar 5. PMID 31969430, Free PMC Article
    5. A SAGE approach to discovery of genes involved in autophagic cell death. Gorski SM, et al. Curr Biol, 2003 Feb 18. PMID 12593804

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-ketoglutarate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial alpha-ketoglutarate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5254-PA
    CG5254-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      750347..758719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297830.1 → NP_001284759.1  uncharacterized protein Dmel_CG5254, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JA11
      Conserved Domains (1) summary
      pfam00153
      Location:140 → 236
      Mito_carr; Mitochondrial carrier protein

    2. NM_130500.4 → NP_569856.2  uncharacterized protein Dmel_CG5254, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569856.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3T2
      Related
      FBpp0070129
      Conserved Domains (2) summary
      PTZ00169
      Location:19 → 301
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:18 → 112
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZN6 Q8SZN6
    Q9V3T2 Q9V3T2
    X2JA11 X2JA11

    Gene LinkOut

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