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    ems empty spiracles [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emsprovided by FlyBase
    Official Full Name
    empty spiraclesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000576
    Locus tag
    Dmel_CG2988
    See related
    AllianceGenome:FB:FBgn0000576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ant; CG2988; Dmel\CG2988; E4; Ems; EMS; W13
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; nervous system development; and spiracle morphogenesis, open tracheal system. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; head epidermis primordium; neuroblasts; and neuromere. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ems in Genome Data Viewer
    Location:
    88A2-88A2; 3-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13901853..13904620)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9727575..9730342)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46239 Neighboring gene E5 Neighboring gene Arginine methyltransferase 9 Neighboring gene Arginine methyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A developmental atlas of male terminalia across twelve species of Drosophila. Urum A, et al. Front Cell Dev Biol, 2024. PMID 38487271, Free PMC Article
    2. Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila. Sen S, et al. Biol Open, 2014 Jul 4. PMID 24996925, Free PMC Article
    3. Conserved roles of ems/Emx and otd/Otx genes in olfactory and visual system development in Drosophila and mouse. Sen S, et al. Open Biol, 2013 May 1. PMID 23635521, Free PMC Article
    4. Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord. Wang YW, et al. Elife, 2022 Jun 20. PMID 35723253, Free PMC Article
    5. Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos. Hauptmann G, et al. Trends Genet, 1994 Aug. PMID 7940754

    See all (268) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The phosphorylation of Hbn, Ems, and Msh may provide further insight into the function of Hipk during development of the Drosophila nervous system.
      Title: Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
    2. Expression and function of empty spiracles gene in olfactory sense organ development.
      Title: Expression and function of the empty spiracles gene in olfactory sense organ development of Drosophila melanogaster.
    3. These results indicate that the anteroposterior patterning gene ems controls the expression of DV genes, and vice versa.
      Title: Ems and Nkx6 are central regulators in dorsoventral patterning of the Drosophila brain.
    4. Data show that Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.
      Title: Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.
    5. ems is required for the olfactory circuitry.
      Title: Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila.
    6. Data show that ems gene is involved in the specification of the anterior brain during embryonic CNS development in Drosophila.
      Title: Anteroposterior regionalization of the brain: genetic and comparative aspects.
    7. ems is expressed in the mature adult brain and is autonomously required for the correct number of cells in the persistently expressing adult-specific lineage.
      Title: Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior head segmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in brain segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pattern specification process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    empty spiracles
    Names
    CG2988-PA
    antenna
    empty spiracle
    empty-spiracle
    empty-spiracles
    ems-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13901853..13904620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169560.2 → NP_731868.1  empty spiracles [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18488, Q9VFQ1
      UniProtKB/TrEMBL
      Q5BIB4
      Related
      FBpp0082326
      Conserved Domains (1) summary
      pfam00046
      Location:392 → 444
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18488.2 P18488
    Q5BIB4 Q5BIB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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