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    Gal beta galactosidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33839, updated on 9-Dec-2024

    Summary

    Official Symbol
    Galprovided by FlyBase
    Official Full Name
    beta galactosidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001089
    Locus tag
    Dmel_CG9092
    See related
    AllianceGenome:FB:FBgn0001089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beta-gal; beta-GAL; beta-Gal-1; CG9092; dbeta-Gal; DmelGal; Dmel\CG9092; gal; lacZ-1
    Summary
    Enables beta-galactosidase activity and protein homodimerization activity. Involved in galactose metabolic process. Predicted to be active in vacuole. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to several human genes including GLB1L (galactosidase beta 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Gal in Genome Data Viewer
    Location:
    26B2-26B2; 2-18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6003574..6006827, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6003574..6006827, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene infertile crescent Neighboring gene Lysine demethylase 5 Neighboring gene Tetraspanin 26A Neighboring gene antisense RNA:CR43866 Neighboring gene uncharacterized protein Neighboring gene Homeodomain protein 2.0

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-galactosidase activity  
    enables beta-galactosidase activity  
    enables beta-galactosidase activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in galactose catabolic process  
    involved_in galactose metabolic process  
    involved_in glycoprotein catabolic process  
    Component Evidence Code Pubs
    is_active_in lysosome  
    is_active_in vacuole  

    General protein information

    Preferred Names
    beta galactosidase
    Names
    CG9092-PA
    CG9092-PB
    Gal-PA
    Gal-PB
    beta-galactosidase
    beta-galactosidase-1
    NP_001260120.1
    NP_608978.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6003574..6006827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273191.1 → NP_001260120.1  beta galactosidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCA6
      Conserved Domains (2) summary
      pfam01301
      Location:52 → 374
      Glyco_hydro_35; Glycosyl hydrolases family 35
      pfam13364
      Location:568 → 635
      BetaGal_dom4_5; Beta-galactosidase jelly roll domain
    2. NM_135134.3 → NP_608978.2  beta galactosidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608978.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMJ5
      Related
      FBpp0078861
      Conserved Domains (2) summary
      pfam01301
      Location:54 → 376
      Glyco_hydro_35; Glycosyl hydrolases family 35
      pfam13364
      Location:570 → 637
      BetaGal_dom4_5; Beta-galactosidase jelly roll domain
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