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    Sps1 Selenophosphate synthetase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sps1provided by FlyBase
    Official Full Name
    Selenophosphate synthetase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261270
    Locus tag
    Dmel_CG8553
    See related
    AllianceGenome:FB:FBgn0261270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142926_at; anon-WO0172774.145; anon-WO0172774.146; CG8553; Dm SelD; Dm-SelD; Dmel\CG8553; dsps1; dSPS1; Dsps1; DSPS1; l(2)k12303; l(2)SH1599; l(2)SH2 1599; ptf1; ptuf; ptuf1; selD; SelD; SelD like; selD/sps1; SeS; SPS1
    Summary
    Predicted to enable ATP binding activity. Involved in negative regulation of mitochondrial fusion and negative regulation of reactive oxygen species metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; brain; embryonic/larval midgut; embryonic/larval optic lobe; and midgut primordium. Orthologous to several human genes including SEPHS2 (selenophosphate synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sps1 in Genome Data Viewer
    Location:
    50E6-50E6; 2-69 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14268772..14270658, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10156277..10158163, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta1,4-N-acetylgalactosaminyltransferase A Neighboring gene uncharacterized protein Neighboring gene convoluted Neighboring gene I[[h]] channel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of a selenophosphate synthetase from a collection of P-lacW insertion mutants in Drosophila. Alsina B, et al. Int J Dev Biol, 1996. PMID 9087708
    2. SelD homolog from Drosophila lacking selenide-dependent monoselenophosphate synthetase activity. Persson BC, et al. J Mol Biol, 1997 Nov 28. PMID 9398525
    3. Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster. Morey M, et al. FEBS Lett, 2003 Jan 16. PMID 12527370
    4. Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation. Lee KH, et al. BMC Genomics, 2011 Aug 24. PMID 21864351, Free PMC Article
    5. patufet, the gene encoding the Drosophila melanogaster homologue of selenophosphate synthetase, is involved in imaginal disc morphogenesis. Alsina B, et al. Mol Gen Genet, 1998 Jan. PMID 9491069

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the selenophosphate synthetase 1 regulate PLP bisynthesis, and the intracellular PLP level affects various biological process such as amino acid metabolism, defense and other important metabolic activities.
      Title: Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation.
    2. in Drosophila, SPS1/SelD regulates the intracellular glutamine by inhibiting GS1 and l(2)01810 expression
      Title: Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells.
    3. Our results strongly suggest that selD haploinsufficiency makes heterozygous flies more sensitive to oxidative stress and add further evidence to the role of selenoproteins as cellular antioxidants
      Title: Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables selenide, water dikinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables selenide, water dikinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables selenide, water dikinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    selenophosphate synthetase 1
    Names
    CG8553-PA
    CG8553-PB
    Selenide,water dikinase
    Sps1-PA
    Sps1-PB
    lethal (2) SH1599
    patufet
    selD-like
    selenophosphate synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14268772..14270658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166045.2 → NP_725374.1  selenophosphate synthetase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18373, O18597, Q0E979, Q9V700
      Related
      FBpp0086691
      Conserved Domains (1) summary
      cd02195
      Location:40 → 376
      SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...

    2. NM_166046.2 → NP_725375.1  selenophosphate synthetase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18373, O18597, Q0E979, Q9V700
      Related
      FBpp0086690
      Conserved Domains (1) summary
      cd02195
      Location:40 → 376
      SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18373.1 O18373

    Gene LinkOut

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