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    Aef1 Adult enhancer factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aef1provided by FlyBase
    Official Full Name
    Adult enhancer factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0005694
    Locus tag
    Dmel_CG5683
    See related
    AllianceGenome:FB:FBgn0005694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AEF-1; aef1; AEF1; CG5683; Dmel\CG5683
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval midgut; olfactory receptor neurons; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aef1 in Genome Data Viewer
    Location:
    78D2-78D2; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21433422..21438639)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21426522..21431739)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene regeneration Neighboring gene long non-coding RNA:CR45954 Neighboring gene barricade Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 1 Neighboring gene Syntaxin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A UAS site substitution approach to the in vivo dissection of promoters: interplay between the GATAb activator and the AEF-1 repressor at a Drosophila ecdysone response unit. Brodu V, et al. Development, 2001 Jul. PMID 11493575
    2. The adult enhancer factor-1, a Drosophila melanogaster transcriptional repressor, modulates the promoter activity of the rat class-I alcohol dehydrogenase-encoding gene. Potter JJ, et al. Gene, 1994 Nov 18. PMID 7959011
    3. Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. Ren B, et al. EMBO J, 1998 Feb 16. PMID 9463385, Free PMC Article
    4. Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. Falb D, et al. Mol Cell Biol, 1992 Sep. PMID 1508206, Free PMC Article
    5. A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man. Falb D, et al. Genes Dev, 1992 Mar. PMID 1547943

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adult enhancer factor 1
    Names
    Adh enhancer factor 1
    Aef1-PA
    Aef1-PB
    Aef1-PC
    Aef1-PD
    CG5683-PA
    CG5683-PB
    CG5683-PC
    CG5683-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21433422..21438639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275228.1 → NP_001262157.1  adult enhancer factor 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG42
      Conserved Domains (2) summary
      sd00017
      Location:186 → 206
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:199 → 223
      zf-H2C2_2; Zinc-finger double domain

    2. NM_168904.3 → NP_730631.1  adult enhancer factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39413, Q0E8C4, Q9VP37
      UniProtKB/TrEMBL
      A4V287
      Related
      FBpp0078005
      Conserved Domains (2) summary
      sd00017
      Location:186 → 206
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:199 → 223
      zf-H2C2_2; Zinc-finger double domain

    3. NM_168903.3 → NP_730630.1  adult enhancer factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39413, Q0E8C4, Q9VP37
      UniProtKB/TrEMBL
      A4V287
      Related
      FBpp0078004
      Conserved Domains (2) summary
      sd00017
      Location:186 → 206
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:199 → 223
      zf-H2C2_2; Zinc-finger double domain

    4. NM_079476.3 → NP_524200.1  adult enhancer factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524200.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39413, Q0E8C4, Q9VP37
      UniProtKB/TrEMBL
      A4V287
      Related
      FBpp0078006
      Conserved Domains (2) summary
      sd00017
      Location:186 → 206
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:199 → 223
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V287 A4V287
    M9PG42 M9PG42
    P39413.1 P39413

    Gene LinkOut

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