gkt glaikit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gktprovided by FlyBase
Official Full Name: glaikitprovided by FlyBase
Primary source: FLYBASE:FBgn0260817
Locus tag: Dmel_CG8825
See related: AllianceGenome:FB:FBgn0260817
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-23Db; c22; CG8825; CG8826; Dmel\CG8825; Gkt; Glaikit; Tdp1; TDP1
Summary: Enables 3'-tyrosyl-DNA phosphodiesterase activity. Involved in central nervous system development and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ectoderm; larval ventral nerve cord; somatic precursor cell; and ventral ectoderm. Used to study spinocerebellar ataxia with axonal neuropathy 1. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3159950..3162399)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3159950..3162399)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

a novel gene identified, glaikit, underlying the axonal bifurcation process
Title: Identification of glaikit in a genome-wide expression profiling for axonal bifurcation of the mushroom body in Drosophila.
study establishes that gkt is the Drosophila TDP1 gene, and that it is critical for neuroprotection, normal longevity, and repair of damaged DNA.
Title: Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).
glaikit (gkt) is essential for the formation of epithelial polarity and for neuronal development during Drosophila embryogenesis.
Title: glaikit is essential for the formation of epithelial polarity and neuronal development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3'-tyrosyl-DNA phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-tyrosyl-DNA phosphodiesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3'-tyrosyl-DNA phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

Names: CG8825-PA; Tyrosyl-DNA phosophodiesterase 1; Tyrosyl-DNA phosphodiesterase 1; anon-23Db; gkt-PA

NP_523465.2

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain