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    nmd no mitochondrial derivative [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nmdprovided by FlyBase
    Official Full Name
    no mitochondrial derivativeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005322
    Locus tag
    Dmel_CG5395
    See related
    AllianceGenome:FB:FBgn0005322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.79; CG5395; clone 1.79; DmCG5395; Dmel\CG5395; l(2)08774; ms(2)4; ms(2)ry4; Msp; Msp1; Nmd
    Summary
    Predicted to enable membrane protein dislocase activity. Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nmd in Genome Data Viewer
    Location:
    31D1-31D1; 2-41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10302173..10303947, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10302173..10303947, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cylindromatosis Neighboring gene antisense RNA:CR44968 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Connell-Crowley L, et al. Mech Dev, 2007 May. PMID 17368005, Free PMC Article
    2. Positive selection near an inversion breakpoint on the neo-X chromosome of Drosophila americana. Evans AL, et al. Genetics, 2007 Nov. PMID 17660565, Free PMC Article
    3. Sustained elongation of sperm tail promoted by local remodeling of giant mitochondria in Drosophila. Noguchi T, et al. Curr Biol, 2011 May 24. PMID 21549602
    4. Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Giardina TJ, et al. Mol Ecol, 2011 Oct. PMID 21902747, Free PMC Article
    5. The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Liu X, et al. Cell Rep, 2015 Dec 15. PMID 26673323, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane protein dislocase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in extraction of mislocalized protein from mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extraction of mislocalized protein from mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    no mitochondrial derivative
    Names
    CG5395-PA
    CG5395-PB
    CG5395-PC
    mitochondrial sorting protein 1
    nmd-PA
    nmd-PB
    nmd-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10302173..10303947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298872.1 → NP_001285801.1  no mitochondrial derivative, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL02
      Conserved Domains (2) summary
      smart00382
      Location:132 → 266
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:135 → 265
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_001298871.1 → NP_001285800.1  no mitochondrial derivative, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J7P4
      Conserved Domains (2) summary
      smart00382
      Location:52 → 186
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:55 → 185
      AAA; ATPase family associated with various cellular activities (AAA)

    3. NM_135529.3 → NP_609373.1  no mitochondrial derivative, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL02
      Related
      FBpp0079654
      Conserved Domains (2) summary
      smart00382
      Location:132 → 266
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:135 → 265
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL02 Q9VL02
    X2J7P4 X2J7P4

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