Bgb Big brother [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bgbprovided by FlyBase
Official Full Name: Big brotherprovided by FlyBase
Primary source: FLYBASE:FBgn0013753
Locus tag: Dmel_CG7959
See related: AllianceGenome:FB:FBgn0013753
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bgb; CG7959; Dmel\CG7959; en(lz)D/9; rpbeta2
Summary: Enables transcription coactivator activity. Involved in regulation of hemocyte proliferation. Located in nucleus. Is expressed in several structures, including central brain primordium; eye disc posterior to the morphogenetic furrow; eye photoreceptor cell; ganglia; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1639711..1640952)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1639711..1640952)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of core-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

Names: Bgb-PA; Bgb-PB; Big-brother; CG7959-PA; CG7959-PB; runt domain partner beta2

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The following sections contain reference sequences that belong to a specific genome build. Explain