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    bbc bb in a boxcar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bbcprovided by FlyBase
    Official Full Name
    bb in a boxcarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033844
    Locus tag
    Dmel_CG6016
    See related
    AllianceGenome:FB:FBgn0033844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bbc; cept; CG6016; dCCS2; Dmel\CG6016; Ept
    Summary
    Predicted to enable diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in endoplasmic reticulum. Is expressed in adult head and adult heart. Used to study retinal disease. Orthologous to several human genes including CHPT1 (choline phosphotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bbc in Genome Data Viewer
    Location:
    50A11-50A13; 2-68 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13486634..13494862, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9374139..9382367, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene crowded by cid Neighboring gene centromere identifier Neighboring gene downstream of receptor kinase Neighboring gene mars Neighboring gene Myb-interacting protein 120 Neighboring gene mitochondrial translation elongation factor Tu 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. Liu Y, et al. PLoS Genet, 2014 Mar. PMID 24603715, Free PMC Article
    2. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
    3. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Lim HY, et al. Genes Dev, 2011 Jan 15. PMID 21245170, Free PMC Article
    4. Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Meltzer S, et al. Cell Rep, 2017 Oct 24. PMID 29069593, Free PMC Article
    5. Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. Midorikawa R, et al. J Neurosci, 2010 Aug 11. PMID 20702701, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diacylglycerol cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bb in a boxcar
    Names
    CDP-ethanolamine phosphotransferase
    CG6016-PA
    CG6016-PB
    CG6016-PC
    CG6016-PE
    bbc-PA
    bbc-PB
    bbc-PC
    bbc-PE
    NP_001246300.1
    NP_001260955.1
    NP_610877.2
    NP_725301.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13486634..13494862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259371.2 → NP_001246300.1  bb in a boxcar, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Y4, U3GRY8
      Conserved Domains (1) summary
      cl00453
      Location:12 → 328
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. NM_165993.3 → NP_725301.1  bb in a boxcar, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9E0, U3GRY8
      Related
      FBpp0086818
      Conserved Domains (1) summary
      cl00453
      Location:12 → 328
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    3. NM_001274026.1 → NP_001260955.1  bb in a boxcar, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFL2, U3GRY8
      Conserved Domains (1) summary
      cl00453
      Location:12 → 333
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    4. NM_137033.4 → NP_610877.2  bb in a boxcar, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610877.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9D9, U3GRY8
      Related
      FBpp0086819
      Conserved Domains (1) summary
      cl00453
      Location:12 → 328
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7Y4 A0A0B4K7Y4
    A0A0B4KFL2 A0A0B4KFL2
    A1Z9D9 A1Z9D9
    A1Z9E0 A1Z9E0
    Q8T9C6 Q8T9C6

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