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    PyK Pyruvate kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42620, updated on 17-Dec-2024

    Summary

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    Official Symbol
    PyKprovided by FlyBase
    Official Full Name
    Pyruvate kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267385
    Locus tag
    Dmel_CG7070
    See related
    AllianceGenome:FB:FBgn0267385
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7070; CG7070; Dmel\CG7070; l(3)rQ178; l(3)r[Q178]; Pk; PK; PKM; Pyk; PYK
    Summary
    Enables pyruvate kinase activity. Involved in glucose homeostasis; pyruvate metabolic process; and response to sucrose. Located in P granule and cytosol. Is expressed in several structures, including adult brain; adult head; adult heart; germline cell; and muscle cell. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PyK in Genome Data Viewer
    Location:
    94A6-94A6; 3-74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22367536..22372746)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18193258..18198468)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene muted Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit F Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of a dosage sensitive region for pyruvate kinase in Drosophila melanogaster. Rust KJ, et al. J Hered, 1985 Jan-Feb. PMID 3920304
    2. Drosophila germ granules are assembled from protein components through different modes of competing interactions with the multi-domain Tudor protein. Wahiduzzaman, et al. FEBS Lett, 2024 Apr. PMID 38499396
    3. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. Schriner SE, et al. PLoS One, 2013. PMID 23704949, Free PMC Article
    4. Mushroom body glycolysis is required for olfactory memory in Drosophila. Wu CL, et al. Neurobiol Learn Mem, 2018 Apr. PMID 29477608
    5. Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster. Simard C, et al. Metabolites, 2020 Sep 6. PMID 32899962, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.
      Title: Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyruvate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate kinase
    Names
    CG7070-PA
    CG7070-PB
    PyK-PA
    PyK-PB
    lethal (3) rQ178
    NP_524448.3
    NP_732723.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22367536..22372746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170004.2 → NP_732723.1  pyruvate kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62619
      Related
      FBpp0083610
      Conserved Domains (2) summary
      cd00288
      Location:25 → 511
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:25 → 508
      pyruv_kin; pyruvate kinase

    2. NM_079724.3 → NP_524448.3  pyruvate kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524448.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGI0, O62619, Q86PE3, Q8MT14, Q9VD24
      Related
      FBpp0083611
      Conserved Domains (2) summary
      cd00288
      Location:46 → 532
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:46 → 529
      pyruv_kin; pyruvate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62619.2 O62619

    Gene LinkOut

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