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    Karybeta3 Karyopherin beta 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Karybeta3provided by FlyBase
    Official Full Name
    Karyopherin beta 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0087013
    Locus tag
    Dmel_CG1059
    See related
    AllianceGenome:FB:FBgn0087013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1059; Dmel\CG1059; Imp beta3; Karbeta3; Kary-beta3; karybeta3; l(3)82CDd; l(3)j3A4; l(3)j7E8
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Located in cytosol. Is expressed in adult head and adult heart. Orthologous to human RANBP6 (RAN binding protein 6) and IPO5 (importin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Karybeta3 in Genome Data Viewer
    Location:
    82C5-82C5; 3-47.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4649176..4654624)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (474898..480346)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44155 Neighboring gene Dorsal interacting protein 2 Neighboring gene ripped pocket Neighboring gene long non-coding RNA:CR44156 Neighboring gene spartin Neighboring gene smallish

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maternal and zygotic control of serotonin biosynthesis are both necessary for Drosophila germband extension. Colas JF, et al. Mech Dev, 1999 Sep. PMID 10495272
    2. Gain of affinity point mutation in the serotonin receptor gene 5-HT2Dro accelerates germband extension movements during Drosophila gastrulation. Schaerlinger B, et al. Dev Dyn, 2007 Apr. PMID 17366631
    3. Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. Colas JF, et al. Mech Dev, 1999 Sep. PMID 10495273
    4. Spatiotemporal gating of Stat nuclear influx by Drosophila Npas4 in collective cell migration. Wu JW, et al. Sci Adv, 2022 Jul 22. PMID 35867785, Free PMC Article
    5. Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Hayward D, et al. Commun Integr Biol, 2014. PMID 25053984, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    karyopherin beta 3
    Names
    CG1059-PA
    CG1059-PB
    Karybeta3-PA
    Karybeta3-PB
    karyopherin beta
    karyopherin-beta3
    lethal (3) 82CDd

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4649176..4654624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079502.3 → NP_524226.1  karyopherin beta 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NQ0, Q9VN44
      Related
      FBpp0078500
      Conserved Domains (4) summary
      cd00020
      Location:405 → 503
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13513
      Location:373 → 427
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:364 → 467
      HEAT_2; HEAT repeats
      sd00044
      Location:357 → 385
      HEAT; HEAT repeat [structural motif]

    2. NM_001275330.1 → NP_001262259.1  karyopherin beta 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NQ0, Q9VN44
      Conserved Domains (4) summary
      cd00020
      Location:405 → 503
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13513
      Location:373 → 427
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:364 → 467
      HEAT_2; HEAT repeats
      sd00044
      Location:357 → 385
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960E2 Q960E2
    Q9VN44 Q9VN44

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