dor deep orange [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dorprovided by FlyBase
Official Full Name: deep orangeprovided by FlyBase
Primary source: FLYBASE:FBgn0000482
Locus tag: Dmel_CG3093
See related: AllianceGenome:FB:FBgn0000482
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3093; Deep-orange; Dmel\CG3093; Dof; Dor; DOR; dor1; EG:171E4.1; FI09617; l(1)2Be; l(1)2Bw; l(1)7; l(1)76; vps18; Vps18; Vps18/dor
Summary: Contributes to syntaxin binding activity. Involved in several processes, including endosomal transport; lysosomal transport; and vesicle organization. Located in endosome; synapse; and vacuole. Part of CORVET complex and HOPS complex. Is active in neuromuscular junction. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval crystal cell; ganglia; and ovary. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 2B5-2B5; 1-0.2 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1665052..1668451)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1559085..1562484)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dDOR is an ecdysone receptor coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling.
Title: dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in endosomal vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	TAS Traceable Author Statement more info	PubMed
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in lysosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in organelle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of SNARE complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretory granule-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking involved in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CORVET complex	IDA Inferred from Direct Assay more info	PubMed
part_of CORVET complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HOPS complex	IDA Inferred from Direct Assay more info	PubMed
part_of HOPS complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of HOPS complex	IPI Inferred from Physical Interaction more info	PubMed
part_of HOPS complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in autophagosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: deep orange

Names: CG3093-PA; Deep-orange; dor-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

1665052..1668451

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057938.5 → NP_477286.2 deep orange [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477286.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24314, Q95R67, Q9W570

Related

FBpp0070259

Conserved Domains (5) summary

smart00299
Location:650 → 797

CLH; Clathrin heavy chain repeat homology

cd00162
Location:884 → 914

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00637
Location:654 → 783

Clathrin; Region in Clathrin and VPS

pfam05131
Location:311 → 464

Pep3_Vps18; Pep3/Vps18/deep orange family

cl24079
Location:828 → 889

Helo_like_N; Fungal N-terminal domain of STAND proteins