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    RhoGAP16F Rho GTPase activating protein at 16F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP16Fprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 16Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030893
    Locus tag
    Dmel_CG7122
    See related
    AllianceGenome:FB:FBgn0030893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7122; Dmel\CG7122
    Summary
    Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in primary tracheal branch. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12); ARHGAP27 (Rho GTPase activating protein 27); and ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP16F in Genome Data Viewer
    Location:
    16F6-16F6; 1-59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18093145..18097413)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17987178..17991446)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Swt1 RNA endoribonuclease Neighboring gene scully Neighboring gene Multivesicular body subunit 12 Neighboring gene TBP-associated factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
    2. Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses. Nath AS, et al. Cell Rep, 2022 Mar 1. PMID 35235794
    3. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article
    4. Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway. Billuart P, et al. Cell, 2001 Oct 19. PMID 11672527
    5. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 16F
    Names
    CG7122-PB
    CG7122-PC
    CG7122-PD
    CG7122-PE
    CG7122-PF
    RhoGAP16F-PB
    RhoGAP16F-PC
    RhoGAP16F-PD
    RhoGAP16F-PE
    RhoGAP16F-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18093145..18097413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298472.1 → NP_001285401.1  Rho GTPase activating protein at 16F, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UND9, Q9VWY8
      Conserved Domains (1) summary
      cd00159
      Location:306 → 487
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. NM_176755.3 → NP_788928.2  Rho GTPase activating protein at 16F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788928.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UND9, Q9VWY8
      Related
      FBpp0074287
      Conserved Domains (1) summary
      cd00159
      Location:306 → 487
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    3. NM_133039.5 → NP_573267.3  Rho GTPase activating protein at 16F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573267.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UND9, Q9VWY8
      Related
      FBpp0298030
      Conserved Domains (1) summary
      cd00159
      Location:306 → 487
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. NM_001258801.2 → NP_001245730.1  Rho GTPase activating protein at 16F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UND9, Q9VWY8
      Conserved Domains (1) summary
      cd00159
      Location:306 → 487
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    5. NM_001298471.1 → NP_001285400.1  Rho GTPase activating protein at 16F, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UND9, X2JCF3
      Conserved Domains (1) summary
      cd00159
      Location:306 → 487
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960F5 Q960F5
    Q9VWY8 Q9VWY8
    X2JCF3 X2JCF3

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