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    Rnf41 ring finger protein 41 [ Mus musculus (house mouse) ]

    Gene ID: 67588, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rnf41provided by MGI
    Official Full Name
    ring finger protein 41provided by MGI
    Primary source
    MGI:MGI:1914838
    See related
    Ensembl:ENSMUSG00000025373 AllianceGenome:MGI:1914838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLRF; Nrdp1; D10Ertd722e; 2210404G21Rik; 4930511A05Rik; 4933415P08Rik
    Summary
    Enables erythropoietin receptor binding activity and interleukin-3 receptor binding activity. Acts upstream of or within negative regulation of mitophagy; protein polyubiquitination; and regulation of hemopoiesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.7), CNS E18 (RPKM 16.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rnf41 in Genome Data Viewer
    Location:
    10 D3; 10 76.55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128247485..128277310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128411616..128441441)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 5 Neighboring gene nucleic acid binding protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127846873-127847141 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127848187-127848374 Neighboring gene STARR-positive B cell enhancer ABC_E6940 Neighboring gene predicted gene, 26347 Neighboring gene nuclear encoded tRNA serine 2 (anticodon CGA) Neighboring gene microRNA 8105

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables erythropoietin receptor binding PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables interleukin-3 receptor binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables receptor tyrosine kinase binding  
    enables receptor tyrosine kinase binding  
    enables small GTPase binding  
    enables small GTPase binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in autophagy  
    involved_in extrinsic apoptotic signaling pathway  
    involved_in extrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within negative regulation of cell migration  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of mitophagy PubMed 
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in proteasomal protein catabolic process  
    involved_in proteasomal protein catabolic process  
    involved_in protein autoubiquitination  
    involved_in protein autoubiquitination  
    acts_upstream_of_or_within protein polyubiquitination PubMed 
    involved_in protein polyubiquitination  
    involved_in protein polyubiquitination  
    acts_upstream_of_or_within regulation of MAPK cascade  
    acts_upstream_of_or_within regulation of lymphocyte differentiation PubMed 
    acts_upstream_of_or_within regulation of myeloid cell differentiation PubMed 
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of reactive oxygen species metabolic process  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network  
    located_in endoplasmic reticulum tubular network  
    located_in endoplasmic reticulum tubular network  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NRDP1
    Names
    RING-type E3 ubiquitin transferase NRDP1
    NP_001157709.1
    NP_080535.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164237.1NP_001157709.1  E3 ubiquitin-protein ligase NRDP1

      See identical proteins and their annotated locations for NP_001157709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript which encodes a functional protein.
      Source sequence(s)
      AK028551, AK045760, BC049078
      Consensus CDS
      CCDS24277.1
      UniProtKB/Swiss-Prot
      Q8BGJ2, Q8BH75, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568
      Related
      ENSMUSP00000100869.4, ENSMUST00000096386.13
      Conserved Domains (2) summary
      cd16634
      Location:1557
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137315
      USP8_interact; USP8 interacting
    2. NM_026259.3NP_080535.2  E3 ubiquitin-protein ligase NRDP1

      See identical proteins and their annotated locations for NP_080535.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK045760, BC049078
      Consensus CDS
      CCDS24277.1
      UniProtKB/Swiss-Prot
      Q8BGJ2, Q8BH75, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568
      Related
      ENSMUSP00000132751.2, ENSMUST00000171342.3
      Conserved Domains (2) summary
      cd16634
      Location:1557
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137315
      USP8_interact; USP8 interacting

    RNA

    1. NR_104288.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK028551, AK045760, BC049078
    2. NR_104289.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK028551, AK031657, AK045760, BC049078
    3. NR_104290.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate internal exon in the 5' region and lacks an internal segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK016825, AK028551, AK045760, BC049078

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128247485..128277310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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