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    Med26 mediator complex subunit 26 [ Mus musculus (house mouse) ]

    Gene ID: 70625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med26provided by MGI
    Official Full Name
    mediator complex subunit 26provided by MGI
    Primary source
    MGI:MGI:1917875
    See related
    Ensembl:ENSMUSG00000045248 AllianceGenome:MGI:1917875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crsp7; 5730493L18Rik
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in several structures, including central nervous system; limb; retina; and tongue. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 35.9), ovary adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med26 in Genome Data Viewer
    Location:
    8 B3.3; 8 35.08 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73248402..73302154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72494555..72548310, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene STARR-positive B cell enhancer ABC_E6662 Neighboring gene microRNA 7068 Neighboring gene solute carrier family 35, member E1 Neighboring gene STARR-positive B cell enhancer ABC_E2267 Neighboring gene uncharacterized LOC102639683 Neighboring gene STARR-seq mESC enhancer starr_21873 Neighboring gene adaptor protein complex AP-2, mu1 pseudogene Neighboring gene predicted gene, 35857 Neighboring gene STARR-positive B cell enhancer ABC_E6663 Neighboring gene STARR-seq mESC enhancer starr_21875 Neighboring gene STARR-positive B cell enhancer ABC_E1760 Neighboring gene small integral membrane protein 7 Neighboring gene transmembrane protein 38A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. Takahashi H, et al. Nat Commun, 2015 Jan 9. PMID 25575120, Free PMC Article
    2. The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis. Gyuris A, et al. Biochim Biophys Acta, 2009 May. PMID 19362612, Free PMC Article
    3. Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Kolonay DW, et al. Front Cell Dev Biol, 2024. PMID 38690566, Free PMC Article
    4. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. Mittler G, et al. EMBO Rep, 2001 Sep. PMID 11559591, Free PMC Article
    5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 26
    Names
    CRSP complex subunit 7
    cofactor required for Sp1 transcriptional activation subunit 7
    cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027485.4 → NP_081761.2  mediator of RNA polymerase II transcription subunit 26

      See identical proteins and their annotated locations for NP_081761.2

      Status: VALIDATED

      Source sequence(s)
      BC054737, BY059601
      Consensus CDS
      CCDS22416.1
      UniProtKB/Swiss-Prot
      Q7TN02, Q8BUP9, Q8R1G7, Q9CS67
      Related
      ENSMUSP00000058697.6, ENSMUST00000058534.7
      Conserved Domains (3) summary
      smart00509
      Location:12 → 86
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:407 → 586
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:178 → 405
      Med26_M; Mediator complex subunit 26 middle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      73248402..73302154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN02.1 GenPept UniProtKB/Swiss-Prot:Q7TN02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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