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    Snx30 sorting nexin family member 30 [ Mus musculus (house mouse) ]

    Gene ID: 209131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx30provided by MGI
    Official Full Name
    sorting nexin family member 30provided by MGI
    Primary source
    MGI:MGI:2443882
    See related
    Ensembl:ENSMUSG00000028385 AllianceGenome:MGI:2443882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732481H14Rik; C030041J06Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including endocytic recycling; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in early endosome membrane. Predicted to be active in early endosome and phagophore assembly site. Is expressed in several structures, including central nervous system; hemolymphoid system; respiratory system; retina; and thyroid gland. Orthologous to human SNX30 (sorting nexin family member 30). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.4), placenta adult (RPKM 4.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx30 in Genome Data Viewer
    Location:
    4 B3; 4 32.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59805137..59904740)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59805131..59904740)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130308A19 gene Neighboring gene predicted gene, 54283 Neighboring gene STARR-seq mESC enhancer starr_10382 Neighboring gene STARR-positive B cell enhancer ABC_E421 Neighboring gene STARR-seq mESC enhancer starr_10383 Neighboring gene STARR-positive B cell enhancer ABC_E7970 Neighboring gene INTS3 and NABP interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E3493 Neighboring gene STARR-positive B cell enhancer ABC_E6184 Neighboring gene STARR-positive B cell enhancer ABC_E9590 Neighboring gene STARR-positive B cell enhancer ABC_E10237 Neighboring gene STARR-seq mESC enhancer starr_10384 Neighboring gene sorting nexin 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59891511-59891739 Neighboring gene STARR-positive B cell enhancer ABC_E4632 Neighboring gene solute carrier family 46, member 2 Neighboring gene major urinary protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106086

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-30
    Names
    novel PX domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172468.2 → NP_766056.1  sorting nexin-30

      See identical proteins and their annotated locations for NP_766056.1

      Status: VALIDATED

      Source sequence(s)
      AK147437, AL831738, BB645079
      Consensus CDS
      CCDS18226.1
      UniProtKB/Swiss-Prot
      Q3UHE6, Q8CE50
      Related
      ENSMUSP00000030080.7, ENSMUST00000030080.7
      Conserved Domains (2) summary
      cd06860
      Location:91 → 206
      PX_SNX7_30_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
      cd07667
      Location:190 → 429
      BAR_SNX30; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 30

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59805137..59904740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537724.3 → XP_006537787.1  sorting nexin-30 isoform X1

      See identical proteins and their annotated locations for XP_006537787.1

      Conserved Domains (2) summary
      cd06860
      Location:1 → 102
      PX_SNX7_30_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
      cl12013
      Location:86 → 325
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_006537725.5 → XP_006537788.1  sorting nexin-30 isoform X1

      See identical proteins and their annotated locations for XP_006537788.1

      Conserved Domains (2) summary
      cd06860
      Location:1 → 102
      PX_SNX7_30_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
      cl12013
      Location:86 → 325
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE50.1 GenPept UniProtKB/Swiss-Prot:Q8CE50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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