Zxdb zinc finger, X-linked, duplicated B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zxdbprovided by MGI
Official Full Name: zinc finger, X-linked, duplicated Bprovided by MGI
Primary source: MGI:MGI:3694898
See related: Ensembl:ENSMUSG00000073062 AllianceGenome:MGI:3694898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zxda
Summary: Predicted to enable C2H2 zinc finger domain binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZXDA (zinc finger X-linked duplicated A) and ZXDB (zinc finger X-linked duplicated B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: X C3; X 41.68 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (93768175..93773793)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (94724569..94730191)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables C2H2 zinc finger domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger X-linked protein ZXDB

Names: zinc finger X-linked protein ZXDA/ZXDB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081473.2 → NP_001074942.1 zinc finger X-linked protein ZXDB

See identical proteins and their annotated locations for NP_001074942.1

Status: VALIDATED

Source sequence(s)

CR293526

Consensus CDS

CCDS41065.1

UniProtKB/Swiss-Prot

A2CE44, Q3V1M7, Q8CEQ1

Related

ENSMUSP00000100524.2, ENSMUST00000101388.4

Conserved Domains (5) summary

COG5048
Location:510 → 642

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:498 → 517

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:585 → 607

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:419 → 442

zf-H2C2_2; Zinc-finger double domain

pfam17017
Location:373 → 518

zf-C2H2_aberr; Aberrant zinc-finger