Fut9 fucosyltransferase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fut9provided by MGI
Official Full Name: fucosyltransferase 9provided by MGI
Primary source: MGI:MGI:1330859
See related: Ensembl:ENSMUSG00000055373 AllianceGenome:MGI:1330859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mFUT9; mFuc-TIX
Summary: Enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in several processes, including Lewis x epitope biosynthetic process; N-glycan fucosylation; and neuronal stem cell division. Acts upstream of or within protein glycosylation. Located in Golgi apparatus. Is expressed in central nervous system and urinary system. Orthologous to human FUT9 (fucosyltransferase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 6.6), cerebellum adult (RPKM 5.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A3; 4 10.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (25609333..25800003, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (25609333..25800003, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It sought to transcriptionally activate the Fut9 gene in the well-known murine colorectal cancer cell line, MC38, which lacks expression of the FUT4 and FUT9 enzymes.
Title: Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells.
N-linked glycan mass spectrometry profile of wild-type mouse kidney glycoproteins revealed the presence of abundant terminal fucoses, which were lost following knockout of the Fut9 gene
Title: Large-Scale Identification of N-Glycan Glycoproteins Carrying Lewis x and Site-Specific N-Glycan Alterations in Fut9 Knockout Mice.
Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens.
Title: Mice lacking α1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens.
We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
FUT9 plays a significant role during human, but not mouse, E-selectin-mediated cell adhesion.
Title: Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.
Mice lacking fut9 demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors.
Title: Mice lacking alpha1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors.
Alpha1,3-fucosyltransferase IX (Fut9)regulates expression of the Lewis X (Lex) carbohydrate structure in brain development
Title: Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

AU067636 (e-PCR)
- UniSTS:178966

RH132294 (e-PCR)
- UniSTS:215577

NoName (e-PCR)
- UniSTS:491314

NoName (e-PCR)
- UniSTS:225081

Fut9 (e-PCR), detects polymorphism
- UniSTS:508003

D4Mit361 (e-PCR), detects polymorphism
- UniSTS:130153

D4Mit2 (e-PCR), detects polymorphism
- UniSTS:129980

AI746471 (e-PCR)
- UniSTS:165311

BB392595 (e-PCR)
- UniSTS:207597

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Lewis x epitope biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Lewis x epitope biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in N-glycan fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in fucosylation	ISO Inferred from Sequence Orthology more info
involved_in glycosphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosphingolipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polysaccharide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	ISO Inferred from Sequence Orthology more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

Names: alpha-(1,3)-fucosyltransferase 9; fuc-TIX; fucT-IX; fucosyltransferase IX; galactoside 3-L-fucosyltransferase

NP_034373.1

EC 2.4.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010243.3 → NP_034373.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

See identical proteins and their annotated locations for NP_034373.1

Status: VALIDATED

Source sequence(s)

AL935336, BB626126, BX323863

Consensus CDS

CCDS18011.1

UniProtKB/Swiss-Prot

O88819, Q3TQ63

UniProtKB/TrEMBL

Q14AE3

Related

ENSMUSP00000081826.5, ENSMUST00000084770.5

Conserved Domains (2) summary

pfam00852
Location:185 → 354

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:62 → 169

Glyco_tran_10_N; Fucosyltransferase, N-terminal