Commd8 COMM domain containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Commd8provided by MGI
Official Full Name: COMM domain containing 8provided by MGI
Primary source: MGI:MGI:1343485
See related: Ensembl:ENSMUSG00000029213 AllianceGenome:MGI:1343485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D5Buc26e
Summary: Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Orthologous to human COMMD8 (COMM domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 7.6), placenta adult (RPKM 7.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.2; 5 38.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (72313919..72325532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (72156576..72168189, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488573

RH126238 (e-PCR)
- UniSTS:162946

D5Buc26e (e-PCR), detects polymorphism
- UniSTS:142517

RH124946 (e-PCR)
- UniSTS:161768

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COMM domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356611.1 → NP_001343540.1 COMM domain-containing protein 8 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC122915, CB247520

Conserved Domains (1) summary

cd04756
Location:6 → 165

Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
NM_001356612.1 → NP_001343541.1 COMM domain-containing protein 8 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC122915, BY150959

UniProtKB/TrEMBL

A0A0G2JEX2

Related

ENSMUSP00000142937.2, ENSMUST00000196241.2

Conserved Domains (1) summary

cl06336
Location:25 → 130

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
NM_001356613.1 → NP_001343542.1 COMM domain-containing protein 8 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate internal exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).

Source sequence(s)

AC122915, AK158078

UniProtKB/TrEMBL

Q80UT2

Conserved Domains (1) summary

cl06336
Location:5 → 110

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
NM_001356614.1 → NP_001343543.1 COMM domain-containing protein 8 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate internal exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).

Source sequence(s)

AC122915, AK017777

UniProtKB/TrEMBL

Q80UT2

Conserved Domains (1) summary

cl06336
Location:5 → 110

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
NM_178599.5 → NP_848714.1 COMM domain-containing protein 8 isoform a

See identical proteins and their annotated locations for NP_848714.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC122915

Consensus CDS

CCDS39108.1

UniProtKB/Swiss-Prot

Q9CZG3, Q9D7F6

UniProtKB/TrEMBL

Q4QQP1

Related

ENSMUSP00000013693.7, ENSMUST00000013693.11

Conserved Domains (1) summary

cd04756
Location:7 → 182

Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

72313919..72325532 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254548.1 → XP_030110408.1 COMM domain-containing protein 8 isoform X1

UniProtKB/TrEMBL

Q80UT2

Conserved Domains (1) summary

cl06336
Location:5 → 110

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
XM_036165159.1 → XP_036021052.1 COMM domain-containing protein 8 isoform X1

UniProtKB/TrEMBL

Q80UT2

Conserved Domains (1) summary

cl06336
Location:5 → 110

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...