Vps36 vacuolar protein sorting 36 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vps36provided by MGI
Official Full Name: vacuolar protein sorting 36provided by MGI
Primary source: MGI:MGI:1917410
See related: Ensembl:ENSMUSG00000031479 AllianceGenome:MGI:1917410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eap45; 1700010A24Rik; 2210415M20Rik; 2810408E15Rik
Summary: Enables ubiquitin binding activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within endosomal transport. Located in late endosome and lysosome. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Orthologous to human VPS36 (vacuolar protein sorting 36 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 12.8), bladder adult (RPKM 12.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.14 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (22682849..22710969)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22192833..22220953)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

presentation of the complex structure of Eap45 GLUE and ubiquitin at 3.35 A resolution, which explains the previously uncharacterized mechanism of Ub recognition by mammalian ESCRT-II
Title: Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosomal transport	IC Inferred by Curator more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT II complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vacuolar protein-sorting-associated protein 36

Names: ESCRT-II complex subunit VPS36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368379.1 → NP_001355308.1 vacuolar protein-sorting-associated protein 36 isoform 2

Status: VALIDATED

Source sequence(s)

AC117665
NM_027338.2 → NP_081614.1 vacuolar protein-sorting-associated protein 36 isoform 1

See identical proteins and their annotated locations for NP_081614.1

Status: VALIDATED

Source sequence(s)

AC117665

Consensus CDS

CCDS22171.1

UniProtKB/Swiss-Prot

Q91XD6, Q9CVA3

UniProtKB/TrEMBL

Q3TSR1

Related

ENSMUSP00000033866.9, ENSMUST00000033866.9

Conserved Domains (2) summary

cd13226
Location:1 → 128

PH-GRAM-like_Eap45; Pleckstrin homology-like domain or GLUE (GRAM-like ubiquitin-binding in Eap45) domain of Eap45

pfam04157
Location:154 → 369

EAP30; EAP30/Vps36 family